Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase

Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase

Estrogens play critical roles in embryonic development, gonadal sex differentiation, behavior, and reproduction in vertebrates and in several human cancers. Estrogens are synthesized from testosterone and androstenedione by the endoplasmic reticulum membrane-bound P450 aromatase/cytochrome P450 oxid...

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Bibliographic Details
Main Authors: Juliane Günther, Gerhard Schuler, Elin Teppa, Rainer Fürbass
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
CYP19 isoforms
helix C
CPR-interacting surface
structural modeling
testosterone
androstenedione
Online Access:https://www.mdpi.com/1422-0067/25/3/1440

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