Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial
Objective: To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participan...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2019-04-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | http://beat.sums.ac.ir/article_45341_9719372688ae705794491e721acc61a5.pdf |
| _version_ | 1818821298666602496 |
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| author | Afsaneh Nowroozi Hanieh Kianipour Houshang Taleby Bijan Yazdi |
| author_facet | Afsaneh Nowroozi Hanieh Kianipour Houshang Taleby Bijan Yazdi |
| author_sort | Afsaneh Nowroozi |
| collection | DOAJ |
| description | Objective: To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were randomly allocated to either groups of propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in propofol group received a bolus dose of 0.5 mg/kg ketamine, plus 0.5 mg/kg propofol. In thiopental group, patients received a bolus dose of 0.5 mg/kg ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients’ pain score (VAS) and any intra-operative recall or awareness were recorded. Statistical analysis was performed using SPSS version 19.0Results: BIS was lower in ketamin-propofol group (p< 0.001). Mean arterial blood pressure, heart rate and O2 saturation showed a significant difference between two groups (p< 0.001), which were lower in ketamin–propofol group. VAS score was higher in ketamin-thiopental group (p< 0.001). Both groups were similar in intra-operative recall/awareness.Conclusion: Ketamine-propofol combination deliver a better control over monitored anesthesia during surgery, providing lower BIS, higher O2 saturation and lower heart rate and arterial blood pressure in patients undergoing minor traumatic orthopedic surgeries.Clinical trial registration: IRCT6N 2016032320258 |
| first_indexed | 2024-12-18T23:05:58Z |
| format | Article |
| id | doaj.art-7b944360832d4650beb1cd746fbf26d1 |
| institution | Directory Open Access Journal |
| issn | 2322-2522 2322-3960 |
| language | English |
| last_indexed | 2024-12-18T23:05:58Z |
| publishDate | 2019-04-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Bulletin of Emergency and Trauma |
| spelling | doaj.art-7b944360832d4650beb1cd746fbf26d12022-12-21T20:48:25ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602019-04-017Issue 211812310.29252/beat-07020545341Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical TrialAfsaneh NowrooziHanieh KianipourHoushang TalebyBijan YazdiObjective: To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were randomly allocated to either groups of propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in propofol group received a bolus dose of 0.5 mg/kg ketamine, plus 0.5 mg/kg propofol. In thiopental group, patients received a bolus dose of 0.5 mg/kg ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients’ pain score (VAS) and any intra-operative recall or awareness were recorded. Statistical analysis was performed using SPSS version 19.0Results: BIS was lower in ketamin-propofol group (p< 0.001). Mean arterial blood pressure, heart rate and O2 saturation showed a significant difference between two groups (p< 0.001), which were lower in ketamin–propofol group. VAS score was higher in ketamin-thiopental group (p< 0.001). Both groups were similar in intra-operative recall/awareness.Conclusion: Ketamine-propofol combination deliver a better control over monitored anesthesia during surgery, providing lower BIS, higher O2 saturation and lower heart rate and arterial blood pressure in patients undergoing minor traumatic orthopedic surgeries.Clinical trial registration: IRCT6N 2016032320258http://beat.sums.ac.ir/article_45341_9719372688ae705794491e721acc61a5.pdfMonitored anesthesia careKetaminPropofolThiopantal sodium |
| spellingShingle | Afsaneh Nowroozi Hanieh Kianipour Houshang Taleby Bijan Yazdi Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial Bulletin of Emergency and Trauma Monitored anesthesia care Ketamin Propofol Thiopantal sodium |
| title | Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial |
| title_full | Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial |
| title_fullStr | Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial |
| title_full_unstemmed | Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial |
| title_short | Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial |
| title_sort | comparison of ketamine propofol and ketamine thiopental on bispectral index values during monitored anesthesia care mac in minor traumatic orthopedic surgery a randomized double blind clinical trial |
| topic | Monitored anesthesia care Ketamin Propofol Thiopantal sodium |
| url | http://beat.sums.ac.ir/article_45341_9719372688ae705794491e721acc61a5.pdf |
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