Ultra-Stable Molecular Sensors by Sub-Micron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part I. The Concept of a Spatial Affinity Lock-in Amplifier

Ultra-Stable Molecular Sensors by Sub-Micron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part I. The Concept of a Spatial Affinity Lock-in Amplifier

Label-free optical biosensors, such as surface plasmon resonance, are sensitive and well-established for the characterization of molecular interactions. Yet, these sensors require stabilization and constant conditions even with the use of reference channels. In this paper, we use tools from signal p...

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Bibliographic Details
Main Authors: Andreas Frutiger, Christof Fattinger, János Vörös
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Sensors
Subjects:
molecular sensors
chemosensors, biosensors
lock-in amplifiers
noise rejection
noise analysis
optical diffraction
Online Access:https://www.mdpi.com/1424-8220/21/2/469

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