Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS
Next to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to generate thymic regulatory T (Treg) cells, an alternative route has been described. This alternative route is characterized by reciprocal induction of Foxp3 and CD25, with CD25 induction being requir...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01583/full |
| _version_ | 1818138741168930816 |
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| author | Marc Schuster Marc Schuster Carlos Plaza-Sirvent Carlos Plaza-Sirvent Alexander Visekruna Jochen Huehn Ingo Schmitz Ingo Schmitz |
| author_facet | Marc Schuster Marc Schuster Carlos Plaza-Sirvent Carlos Plaza-Sirvent Alexander Visekruna Jochen Huehn Ingo Schmitz Ingo Schmitz |
| author_sort | Marc Schuster |
| collection | DOAJ |
| description | Next to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to generate thymic regulatory T (Treg) cells, an alternative route has been described. This alternative route is characterized by reciprocal induction of Foxp3 and CD25, with CD25 induction being required to rescue developing Treg cells from Foxp3-induced apoptosis. NF-κB has been demonstrated to be crucial for the development of thymic Treg cells via the classical route. However, its impact on the alternative route is poorly characterized. Using single and double deficient mice for key regulators of the classical route, c-Rel and IκBNS, we here demonstrate that NF-κB is essential for the generation of alternative CD25−Foxp3+ precursors, as well. Thus, c-Rel and IκBNS govern both routes of thymic Treg cell development. |
| first_indexed | 2024-12-11T10:17:01Z |
| format | Article |
| id | doaj.art-7b9527e8aa264fe28fa9bb818f4d1699 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T10:17:01Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7b9527e8aa264fe28fa9bb818f4d16992022-12-22T01:11:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01583460324Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNSMarc Schuster0Marc Schuster1Carlos Plaza-Sirvent2Carlos Plaza-Sirvent3Alexander Visekruna4Jochen Huehn5Ingo Schmitz6Ingo Schmitz7Systems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyMedical Faculty, Institute for Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, GermanySystems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyMedical Faculty, Institute for Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, GermanyInstitute for Medical Microbiology and Hygiene, Biomedical Research Center (BMFZ), Philipps University of Marburg, Marburg, GermanyDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanySystems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyMedical Faculty, Institute for Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, GermanyNext to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to generate thymic regulatory T (Treg) cells, an alternative route has been described. This alternative route is characterized by reciprocal induction of Foxp3 and CD25, with CD25 induction being required to rescue developing Treg cells from Foxp3-induced apoptosis. NF-κB has been demonstrated to be crucial for the development of thymic Treg cells via the classical route. However, its impact on the alternative route is poorly characterized. Using single and double deficient mice for key regulators of the classical route, c-Rel and IκBNS, we here demonstrate that NF-κB is essential for the generation of alternative CD25−Foxp3+ precursors, as well. Thus, c-Rel and IκBNS govern both routes of thymic Treg cell development.https://www.frontiersin.org/article/10.3389/fimmu.2019.01583/fullcell differentiationcommon γ-chain cytokinesNF-κBregulatory T cellthymustranscription factor |
| spellingShingle | Marc Schuster Marc Schuster Carlos Plaza-Sirvent Carlos Plaza-Sirvent Alexander Visekruna Jochen Huehn Ingo Schmitz Ingo Schmitz Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS Frontiers in Immunology cell differentiation common γ-chain cytokines NF-κB regulatory T cell thymus transcription factor |
| title | Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS |
| title_full | Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS |
| title_fullStr | Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS |
| title_full_unstemmed | Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS |
| title_short | Generation of Foxp3+CD25− Regulatory T-Cell Precursors Requires c-Rel and IκBNS |
| title_sort | generation of foxp3 cd25 regulatory t cell precursors requires c rel and iκbns |
| topic | cell differentiation common γ-chain cytokines NF-κB regulatory T cell thymus transcription factor |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01583/full |
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