Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment
A biomimetic coating was prepared on β-titanium alloy surface using micro-arc oxidation to enhance its bone regeneration property in diabetic environment. The research probed into the complex interactions between crystalline phase, chemical composition, and surface morphology in modulating osteoblas...
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Elsevier
2024-03-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524001801 |
| _version_ | 1797256420451680256 |
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| author | Dong Li Yajing Chen Ran Li Zhimin Chen Kun Qian Zhuan Zou Weizhou Li Quanzhi Chen |
| author_facet | Dong Li Yajing Chen Ran Li Zhimin Chen Kun Qian Zhuan Zou Weizhou Li Quanzhi Chen |
| author_sort | Dong Li |
| collection | DOAJ |
| description | A biomimetic coating was prepared on β-titanium alloy surface using micro-arc oxidation to enhance its bone regeneration property in diabetic environment. The research probed into the complex interactions between crystalline phase, chemical composition, and surface morphology in modulating osteoblast behavior. The resultant coating displayed an open, porous structure, characterized by surface porosities ranging from 19.3 % to 39.8 % and a roughness distribution spanning 22.9 to 37.9 nm. XRD and XPS analyses confirmed a hydroxyapatite crystal structure within the coatings. Elemental quantification revealed Ca/P ratios from 1.49 to 2.44, aligning closely with the physiological bone ratio of 1.67. Under the synergistic effects of hyperglycemia and advanced glycation end-products (AGES), Ca and P ion release from the MAO coating was expedited, thereby inducing osteogenic differentiation of bone marrow stem cells. In addition, the Ca2+ released from the coating would complex with AGES, reducing its inhibitory effect on cell growth and thus promoting cell proliferation. Cellular experiments showed that higher coating porosity and its beneficial ions release facilitated the growth environment and promoted cell proliferation and differentiation. This study utilized coating design and corrosion phenomena to provide a theoretical basis for titanium alloys in clinical applications. |
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| id | doaj.art-7b96585aa2654b82a63ae085d56e96c8 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-24T22:21:28Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
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| series | Materials & Design |
| spelling | doaj.art-7b96585aa2654b82a63ae085d56e96c82024-03-20T06:08:26ZengElsevierMaterials & Design0264-12752024-03-01239112808Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environmentDong Li0Yajing Chen1Ran Li2Zhimin Chen3Kun Qian4Zhuan Zou5Weizhou Li6Quanzhi Chen7School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, Guangxi, ChinaSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, ChinaSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, ChinaSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, ChinaSchool of Materials Science and Engineering, Southeast University, Nanjing 211189, Jiangsu, ChinaThe First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi, China; Corresponding authors at: The First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi, China (Zhuan Zou), School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China (Weizhou Li), School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, China (Quanzhi Chen).School of Resources, Environment and Materials, Guangxi University, Nanning 530004, Guangxi, China; School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China; Corresponding authors at: The First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi, China (Zhuan Zou), School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China (Weizhou Li), School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, China (Quanzhi Chen).School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, China; Corresponding authors at: The First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi, China (Zhuan Zou), School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China (Weizhou Li), School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, China (Quanzhi Chen).A biomimetic coating was prepared on β-titanium alloy surface using micro-arc oxidation to enhance its bone regeneration property in diabetic environment. The research probed into the complex interactions between crystalline phase, chemical composition, and surface morphology in modulating osteoblast behavior. The resultant coating displayed an open, porous structure, characterized by surface porosities ranging from 19.3 % to 39.8 % and a roughness distribution spanning 22.9 to 37.9 nm. XRD and XPS analyses confirmed a hydroxyapatite crystal structure within the coatings. Elemental quantification revealed Ca/P ratios from 1.49 to 2.44, aligning closely with the physiological bone ratio of 1.67. Under the synergistic effects of hyperglycemia and advanced glycation end-products (AGES), Ca and P ion release from the MAO coating was expedited, thereby inducing osteogenic differentiation of bone marrow stem cells. In addition, the Ca2+ released from the coating would complex with AGES, reducing its inhibitory effect on cell growth and thus promoting cell proliferation. Cellular experiments showed that higher coating porosity and its beneficial ions release facilitated the growth environment and promoted cell proliferation and differentiation. This study utilized coating design and corrosion phenomena to provide a theoretical basis for titanium alloys in clinical applications.http://www.sciencedirect.com/science/article/pii/S0264127524001801β-Titanium alloyMAO coatingHyperglycemiaDiabetic environmentBone regeneration |
| spellingShingle | Dong Li Yajing Chen Ran Li Zhimin Chen Kun Qian Zhuan Zou Weizhou Li Quanzhi Chen Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment Materials & Design β-Titanium alloy MAO coating Hyperglycemia Diabetic environment Bone regeneration |
| title | Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment |
| title_full | Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment |
| title_fullStr | Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment |
| title_full_unstemmed | Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment |
| title_short | Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment |
| title_sort | preparation of biomimetic mao coating on β titanium alloy surface and its bone regeneration property in diabetic environment |
| topic | β-Titanium alloy MAO coating Hyperglycemia Diabetic environment Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524001801 |
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