Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK‐p25, 5XFAD, and Tau P301S mouse models of neurodegenerat...

Full description

Bibliographic Details
Main Authors: Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
Format: Article
Language:English
Published: Springer Nature 2020-12-01
Series:Molecular Systems Biology
Subjects:
Alzheimer's disease
microglia
phosphoproteomics
Siglec‐8
Siglec‐F
Online Access:https://doi.org/10.15252/msb.20209819

Similar Items

Similar Items