Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study
Purpose: To determine whether exercise training might exert anti-inflammatory effect by reducing HMGB1 levels in women with breast cancer (BC). Methods: We analyzed monocentric data from the DIANA (DIET AND ANDROGENS)-5 PROJECT. Study population consisted of 94 patients randomized into two groups: 6...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2015-08-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/45 |
| _version_ | 1828834559745064960 |
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| author | Francesco Giallauria Marco Gentile Paolo Chiodini Franco Berrino Amalia Mattiello Luigi Maresca Alessandra Vitelli Maria Mancini Alessandra Grieco Angelo Russo Rosa Lucci Giorgio Torella Salvatore Panico Carlo Vigorito |
| author_facet | Francesco Giallauria Marco Gentile Paolo Chiodini Franco Berrino Amalia Mattiello Luigi Maresca Alessandra Vitelli Maria Mancini Alessandra Grieco Angelo Russo Rosa Lucci Giorgio Torella Salvatore Panico Carlo Vigorito |
| author_sort | Francesco Giallauria |
| collection | DOAJ |
| description | Purpose: To determine whether exercise training might exert anti-inflammatory effect by reducing HMGB1 levels in women with breast cancer (BC). Methods: We analyzed monocentric data from the DIANA (DIET AND ANDROGENS)-5 PROJECT. Study population consisted of 94 patients randomized into two groups: 61 patients (53±8 yrs, training group) were assigned to a structured exercise training intervention (3 times/week for the first 3 months, and once /week for the following 9 months); whereas 33 patients (52±7 yrs, control group) followed only the general indications to adhere to the life-style intervention suggestions of the DIANA protocol. At study entry and after 12 months, all patients underwent cardiopulmonary exercise testing, biochemical assessment [HMGB1, high-sensitivity C-reactive protein (hs- CRP), interleukin-6 (IL-6)]; and lipid and glycemic profile. Results: There were no significant differences between groups in baseline clinical and inflammatory profile. Among the training group, only 19/61 patients had high adherence to the exercise intervention. After stratifying the study population according to the level of adhesion to the exercise intervention, 1-year HMGB1 levels were lower among patients more adherent to exercise (p for trend=0.001). Further adjusting for age, body mass index and baseline values, 1-year HMGB1 levels remained significantly and inversely associated to the level of adhesion to the exercise intervention (B=-0.97, SE=0.43, p=0.01). Conclusions: Moderate intensity exercise training in BC survivors is associated with reduced HMGB1 levels that are proportional to the level of adhesion to the exercise intervention, independently from other classical inflammatory molecules, suggesting an exercise-induced anti-inflammatory effect mediated by HMGB1. |
| first_indexed | 2024-12-12T17:41:58Z |
| format | Article |
| id | doaj.art-7b96e26e7e7d4c9b8d9cdad55f029e38 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-12T17:41:58Z |
| publishDate | 2015-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-7b96e26e7e7d4c9b8d9cdad55f029e382022-12-22T00:17:02ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642015-08-0182210.4081/monaldi.2014.45Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 studyFrancesco Giallauria0Marco Gentile1Paolo Chiodini2Franco Berrino3Amalia Mattiello4Luigi Maresca5Alessandra Vitelli6Maria Mancini7Alessandra Grieco8Angelo Russo9Rosa Lucci10Giorgio Torella11Salvatore Panico12Carlo Vigorito13Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDipartimento di Medicina Clinica e Chirurgia, Federico II University, NaplesMedical Statistics Unit, Second University of Naples, NaplesDepartment of Preventive and Predictive Medicine, National Cancer Institute, MilanDipartimento di Medicina Clinica e Chirurgia, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesDipartimento di Medicina Clinica e Chirurgia, Federico II University, NaplesDepartment of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation, Federico II University, NaplesPurpose: To determine whether exercise training might exert anti-inflammatory effect by reducing HMGB1 levels in women with breast cancer (BC). Methods: We analyzed monocentric data from the DIANA (DIET AND ANDROGENS)-5 PROJECT. Study population consisted of 94 patients randomized into two groups: 61 patients (53±8 yrs, training group) were assigned to a structured exercise training intervention (3 times/week for the first 3 months, and once /week for the following 9 months); whereas 33 patients (52±7 yrs, control group) followed only the general indications to adhere to the life-style intervention suggestions of the DIANA protocol. At study entry and after 12 months, all patients underwent cardiopulmonary exercise testing, biochemical assessment [HMGB1, high-sensitivity C-reactive protein (hs- CRP), interleukin-6 (IL-6)]; and lipid and glycemic profile. Results: There were no significant differences between groups in baseline clinical and inflammatory profile. Among the training group, only 19/61 patients had high adherence to the exercise intervention. After stratifying the study population according to the level of adhesion to the exercise intervention, 1-year HMGB1 levels were lower among patients more adherent to exercise (p for trend=0.001). Further adjusting for age, body mass index and baseline values, 1-year HMGB1 levels remained significantly and inversely associated to the level of adhesion to the exercise intervention (B=-0.97, SE=0.43, p=0.01). Conclusions: Moderate intensity exercise training in BC survivors is associated with reduced HMGB1 levels that are proportional to the level of adhesion to the exercise intervention, independently from other classical inflammatory molecules, suggesting an exercise-induced anti-inflammatory effect mediated by HMGB1.https://www.monaldi-archives.org/index.php/macd/article/view/45cancerbreast cancerhigh mobility group box 1 proteinexercise trainingcardiopulmonary exercise testing |
| spellingShingle | Francesco Giallauria Marco Gentile Paolo Chiodini Franco Berrino Amalia Mattiello Luigi Maresca Alessandra Vitelli Maria Mancini Alessandra Grieco Angelo Russo Rosa Lucci Giorgio Torella Salvatore Panico Carlo Vigorito Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study Monaldi Archives for Chest Disease cancer breast cancer high mobility group box 1 protein exercise training cardiopulmonary exercise testing |
| title | Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study |
| title_full | Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study |
| title_fullStr | Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study |
| title_full_unstemmed | Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study |
| title_short | Exercise training reduces high mobility group box-1 protein levels in women with breast cancer: findings from the DIANA-5 study |
| title_sort | exercise training reduces high mobility group box 1 protein levels in women with breast cancer findings from the diana 5 study |
| topic | cancer breast cancer high mobility group box 1 protein exercise training cardiopulmonary exercise testing |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/45 |
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