Online Quantification of Lactate Concentration in Microdialysate During Cerebral Activation Using 1H-MRS and Sensitive NMR Microcoil

Online Quantification of Lactate Concentration in Microdialysate During Cerebral Activation Using 1H-MRS and Sensitive NMR Microcoil

The dynamic in vivo profiling of lactate is of uppermost importance in both neuroenergetics and neuroprotection fields, considering its central suspected role as a metabolic and signaling molecule. For this purpose, we implemented proton magnetic resonance spectroscopy (1H-MRS) directly on brain mic...

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Bibliographic Details
Main Authors: Yannick Crémillieux, Ursule Dumont, Leslie Mazuel, Roberto Salvati, Vanessa Zhendre, Silvia Rizzitelli, Jordy Blanc, Hélène Roumes, Noël Pinaud, Anne-Karine Bouzier-Sore
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
barrel cortex
lactate
microdialysis
1H-MRS
NMR microcoil
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00089/full

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