Bone morphogenetic protein 10 and atrial fibrillation
Background: The association between bone morphogenetic protein 10 (BMP10) and atrial fibrillation (AF) has been widely investigated by observational studies, but their causal relationships remain inconclusive. Here, we aimed to evaluate the causal effect of BMP10 on the risk of AF through single-nuc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724000423 |
| _version_ | 1827289760115195904 |
|---|---|
| author | Liang Liu Yi Liang Qi-Gang Lan Jun-Zhang Chen Rui Wang Jing-Hong Zhao Bo Liang |
| author_facet | Liang Liu Yi Liang Qi-Gang Lan Jun-Zhang Chen Rui Wang Jing-Hong Zhao Bo Liang |
| author_sort | Liang Liu |
| collection | DOAJ |
| description | Background: The association between bone morphogenetic protein 10 (BMP10) and atrial fibrillation (AF) has been widely investigated by observational studies, but their causal relationships remain inconclusive. Here, we aimed to evaluate the causal effect of BMP10 on the risk of AF through single-nucleotide polymorphisms. Methods: A Mendelian randomization (MR) analytic framework was applied to data from two BMP10-specific genome-wide association studies comprising a total of 11,036,163 single-nucleotide polymorphisms of European ancestry. Instrument genetic variants associated with BMP10 were selected. A total of 12 AF-specific genome-wide association studies comprising a total of 5,095,117 European participants were included. Summary statistic-based methods of inverse variance weighted, MR Egger, weighted median, simple mode, and weighted mode methods were used. Pleiotropy and sensitivity were assessed. Results: Specific to AF-specific genome-wide association studies, we found that BMP10 was not associated with AF among different methods (all P > 0.05). We further identified no significant horizontal pleiotropy (all P > 0.05) and no fundamental impact among various data. Conclusions: This large-scale population study upon data from BMP10- and AF-specific genome-wide association studies and a longitudinal biobank cohort indicates plausible non-causal associations between BMP10 and AF in the European populations. Further studies regarding ancestral diversity are warranted to validate such causal associations. |
| first_indexed | 2024-04-24T11:56:35Z |
| format | Article |
| id | doaj.art-7b98900794c04b239067f32685444078 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-24T11:56:35Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-7b98900794c04b239067f326854440782024-04-09T04:13:17ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-04-0151101376Bone morphogenetic protein 10 and atrial fibrillationLiang Liu0Yi Liang1Qi-Gang Lan2Jun-Zhang Chen3Rui Wang4Jing-Hong Zhao5Bo Liang6Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Geriatrics, Sichuan Second Hospital of T.C.M., Chengdu, ChinaDepartment of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaDepartment of Massage, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China; Corresponding authors.Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China; Corresponding authors.Background: The association between bone morphogenetic protein 10 (BMP10) and atrial fibrillation (AF) has been widely investigated by observational studies, but their causal relationships remain inconclusive. Here, we aimed to evaluate the causal effect of BMP10 on the risk of AF through single-nucleotide polymorphisms. Methods: A Mendelian randomization (MR) analytic framework was applied to data from two BMP10-specific genome-wide association studies comprising a total of 11,036,163 single-nucleotide polymorphisms of European ancestry. Instrument genetic variants associated with BMP10 were selected. A total of 12 AF-specific genome-wide association studies comprising a total of 5,095,117 European participants were included. Summary statistic-based methods of inverse variance weighted, MR Egger, weighted median, simple mode, and weighted mode methods were used. Pleiotropy and sensitivity were assessed. Results: Specific to AF-specific genome-wide association studies, we found that BMP10 was not associated with AF among different methods (all P > 0.05). We further identified no significant horizontal pleiotropy (all P > 0.05) and no fundamental impact among various data. Conclusions: This large-scale population study upon data from BMP10- and AF-specific genome-wide association studies and a longitudinal biobank cohort indicates plausible non-causal associations between BMP10 and AF in the European populations. Further studies regarding ancestral diversity are warranted to validate such causal associations.http://www.sciencedirect.com/science/article/pii/S2352906724000423BMP10Atrial fibrillationMendelian randomization |
| spellingShingle | Liang Liu Yi Liang Qi-Gang Lan Jun-Zhang Chen Rui Wang Jing-Hong Zhao Bo Liang Bone morphogenetic protein 10 and atrial fibrillation International Journal of Cardiology: Heart & Vasculature BMP10 Atrial fibrillation Mendelian randomization |
| title | Bone morphogenetic protein 10 and atrial fibrillation |
| title_full | Bone morphogenetic protein 10 and atrial fibrillation |
| title_fullStr | Bone morphogenetic protein 10 and atrial fibrillation |
| title_full_unstemmed | Bone morphogenetic protein 10 and atrial fibrillation |
| title_short | Bone morphogenetic protein 10 and atrial fibrillation |
| title_sort | bone morphogenetic protein 10 and atrial fibrillation |
| topic | BMP10 Atrial fibrillation Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724000423 |
| work_keys_str_mv | AT liangliu bonemorphogeneticprotein10andatrialfibrillation AT yiliang bonemorphogeneticprotein10andatrialfibrillation AT qiganglan bonemorphogeneticprotein10andatrialfibrillation AT junzhangchen bonemorphogeneticprotein10andatrialfibrillation AT ruiwang bonemorphogeneticprotein10andatrialfibrillation AT jinghongzhao bonemorphogeneticprotein10andatrialfibrillation AT boliang bonemorphogeneticprotein10andatrialfibrillation |