Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review
(1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2688 |
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| author | Ciro Emiliano Boschetti Rita Vitagliano Gianmaria Imola Nicola Cornacchini Maria Luisa Colella Gianpaolo Tartaro Giuseppe Colella |
| author_facet | Ciro Emiliano Boschetti Rita Vitagliano Gianmaria Imola Nicola Cornacchini Maria Luisa Colella Gianpaolo Tartaro Giuseppe Colella |
| author_sort | Ciro Emiliano Boschetti |
| collection | DOAJ |
| description | (1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor, ESTFs have an unpredictable clinical behavior. (2) Methods: We present two clinical cases referred to our Maxillofacial Surgery Unit for the onset of a symptomless mass involving, in one case, the parotid gland, and in the other case, the sublingual gland. (3) Results: Solitary fibrous tumors could be considered as neoplasms with intermediate biological behavior that are not entirely predictable on the basis of morphological features, as these are mostly still unknown. However, a few histologic, immunohistochemical, and imaging features, such as a hypodense signal at the T1 sequence in an MRI, or positivity for CD34, bcl2, and CD99, and the NAB2-STATS6 fusion gene, could be useful for an early differential diagnosis of ESTFs. (4) Conclusions: All patients were alive at follow-up with no evidence of disease. Surgical management should always be considered as the first choice for oncological radicality, and clinical behavior should always be defined with the help of the study of radiological and anatomopathological features. |
| first_indexed | 2024-03-09T19:09:26Z |
| format | Article |
| id | doaj.art-7b9baa2006e045d6963538b2b6cf95d1 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:09:26Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7b9baa2006e045d6963538b2b6cf95d12023-11-24T04:19:21ZengMDPI AGDiagnostics2075-44182022-11-011211268810.3390/diagnostics12112688Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature ReviewCiro Emiliano Boschetti0Rita Vitagliano1Gianmaria Imola2Nicola Cornacchini3Maria Luisa Colella4Gianpaolo Tartaro5Giuseppe Colella6Oral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOral and Maxillofacial Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Special- 8 ties, University of Campania “Luigi Vanvitelli”, Via Luigi de Crecchio, 6, 80138 Naples, Italy(1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor, ESTFs have an unpredictable clinical behavior. (2) Methods: We present two clinical cases referred to our Maxillofacial Surgery Unit for the onset of a symptomless mass involving, in one case, the parotid gland, and in the other case, the sublingual gland. (3) Results: Solitary fibrous tumors could be considered as neoplasms with intermediate biological behavior that are not entirely predictable on the basis of morphological features, as these are mostly still unknown. However, a few histologic, immunohistochemical, and imaging features, such as a hypodense signal at the T1 sequence in an MRI, or positivity for CD34, bcl2, and CD99, and the NAB2-STATS6 fusion gene, could be useful for an early differential diagnosis of ESTFs. (4) Conclusions: All patients were alive at follow-up with no evidence of disease. Surgical management should always be considered as the first choice for oncological radicality, and clinical behavior should always be defined with the help of the study of radiological and anatomopathological features.https://www.mdpi.com/2075-4418/12/11/2688solitary extrapleural fibrous tumorparotid glandsubmandibular glandsublingual glandsalivary glandmalignancies |
| spellingShingle | Ciro Emiliano Boschetti Rita Vitagliano Gianmaria Imola Nicola Cornacchini Maria Luisa Colella Gianpaolo Tartaro Giuseppe Colella Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review Diagnostics solitary extrapleural fibrous tumor parotid gland submandibular gland sublingual gland salivary gland malignancies |
| title | Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review |
| title_full | Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review |
| title_fullStr | Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review |
| title_full_unstemmed | Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review |
| title_short | Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review |
| title_sort | solitary extrapleural fibrous tumor in salivary glands our experience case series and literature review |
| topic | solitary extrapleural fibrous tumor parotid gland submandibular gland sublingual gland salivary gland malignancies |
| url | https://www.mdpi.com/2075-4418/12/11/2688 |
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