Activity of Brazilian and Bulgarian propolis against different species of Leishmania
Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species - Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World - associated to different clinical forms of leishmaniasis. The composition of the extra...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2007-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100012&lng=en&tlng=en |
| _version_ | 1797703048044216320 |
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| author | Gérzia Maria de Carvalho Machado Leonor Laura Leon Solange Lisboa de Castro |
| author_facet | Gérzia Maria de Carvalho Machado Leonor Laura Leon Solange Lisboa de Castro |
| author_sort | Gérzia Maria de Carvalho Machado |
| collection | DOAJ |
| description | Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species - Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World - associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 µg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species. |
| first_indexed | 2024-03-12T04:58:45Z |
| format | Article |
| id | doaj.art-7b9c2eb5f8c542d7b1aefca37044606e |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:58:45Z |
| publishDate | 2007-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-7b9c2eb5f8c542d7b1aefca37044606e2023-09-03T09:14:29ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602007-02-011021737710.1590/S0074-02762007000100012S0074-02762007000100012Activity of Brazilian and Bulgarian propolis against different species of LeishmaniaGérzia Maria de Carvalho Machado0Leonor Laura Leon1Solange Lisboa de Castro2Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzExtracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species - Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World - associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 µg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100012&lng=en&tlng=enLeishmanialeishmaniasispropolischemical compositionnatural products |
| spellingShingle | Gérzia Maria de Carvalho Machado Leonor Laura Leon Solange Lisboa de Castro Activity of Brazilian and Bulgarian propolis against different species of Leishmania Memorias do Instituto Oswaldo Cruz Leishmania leishmaniasis propolis chemical composition natural products |
| title | Activity of Brazilian and Bulgarian propolis against different species of Leishmania |
| title_full | Activity of Brazilian and Bulgarian propolis against different species of Leishmania |
| title_fullStr | Activity of Brazilian and Bulgarian propolis against different species of Leishmania |
| title_full_unstemmed | Activity of Brazilian and Bulgarian propolis against different species of Leishmania |
| title_short | Activity of Brazilian and Bulgarian propolis against different species of Leishmania |
| title_sort | activity of brazilian and bulgarian propolis against different species of leishmania |
| topic | Leishmania leishmaniasis propolis chemical composition natural products |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000100012&lng=en&tlng=en |
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