Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication

Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication

RNase P ribozyme can be engineered to be a sequence-specific gene-targeting agent with promising application in both basic research and clinical settings. By using an in vitro selection system, we have previously generated RNase P ribozyme variants that have better catalytic activity in cleaving an...

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Bibliographic Details
Main Authors: Zhu Yang, Gia-Phong Vu, Hua Qian, Yuan-Chuan Chen, Yu Wang, Michael Reeves, Ke Zen, Fenyong Liu
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Viruses
Subjects:
ribozyme
RNase P
gene targeting
cytomegalovirus
Online Access:http://www.mdpi.com/1999-4915/6/6/2376

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