Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition
Protein tyrosine phosphatase 1B (PTP1B) is important in the regulationof metabolic diseases and has emerged as a promising signalingtarget. Previously, we reported the PTP1B inhibitory activityof Rheum undulatum (RU). In the present study, we investigatedthe metabolic regulatory effects of RU in a h...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Biochemistry and Molecular Biology
2012-03-01
|
| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0zJTVEMTIwMzI3MTU0NV8lMjgxNDEtMTQ2JTI5Qk1CMTEtMjEyLnBkZg== |
| _version_ | 1831738701038747648 |
|---|---|
| author | Woojung Lee Goo Yoon Ye Ran Hwang Yong Kee Kim Su-Nam Kim |
| author_facet | Woojung Lee Goo Yoon Ye Ran Hwang Yong Kee Kim Su-Nam Kim |
| author_sort | Woojung Lee |
| collection | DOAJ |
| description | Protein tyrosine phosphatase 1B (PTP1B) is important in the regulationof metabolic diseases and has emerged as a promising signalingtarget. Previously, we reported the PTP1B inhibitory activityof Rheum undulatum (RU). In the present study, we investigatedthe metabolic regulatory effects of RU in a high-fat diet(HFD) model. RU treatment significantly blocked body weightgain, which was accompanied by a reduction of feed efficiency.In addition, it led to a reduction of liver weight mediated by overexpressionof PPARα and CPT1 in the liver, and an increase in theexpression of adiponectin, aP2, and UCP3 in adipose tissue responsiblefor the reduction of total and LDL-cholesterol levels.Chrysophanol and physcion from RU significantly inhibitedPTP1B activity and strongly enhanced insulin sensitivity.Altogether, our findings strongly suggest that 2 compounds arenovel PTP1B inhibitors and might be considered as anti-obesityagents that are effective for suppressing body weight gain and improvinglipid homeostasis. [BMB reports 2012; 45(3): 141-146] |
| first_indexed | 2024-12-21T13:25:47Z |
| format | Article |
| id | doaj.art-7b9dab8ddc3e4216a8f746c65821f152 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-21T13:25:47Z |
| publishDate | 2012-03-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-7b9dab8ddc3e4216a8f746c65821f1522022-12-21T19:02:27ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2012-03-01453141146http://dx.doi.org/10.5483/BMBRep.2012.45.3.141Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibitionWoojung LeeGoo YoonYe Ran HwangYong Kee KimSu-Nam KimProtein tyrosine phosphatase 1B (PTP1B) is important in the regulationof metabolic diseases and has emerged as a promising signalingtarget. Previously, we reported the PTP1B inhibitory activityof Rheum undulatum (RU). In the present study, we investigatedthe metabolic regulatory effects of RU in a high-fat diet(HFD) model. RU treatment significantly blocked body weightgain, which was accompanied by a reduction of feed efficiency.In addition, it led to a reduction of liver weight mediated by overexpressionof PPARα and CPT1 in the liver, and an increase in theexpression of adiponectin, aP2, and UCP3 in adipose tissue responsiblefor the reduction of total and LDL-cholesterol levels.Chrysophanol and physcion from RU significantly inhibitedPTP1B activity and strongly enhanced insulin sensitivity.Altogether, our findings strongly suggest that 2 compounds arenovel PTP1B inhibitors and might be considered as anti-obesityagents that are effective for suppressing body weight gain and improvinglipid homeostasis. [BMB reports 2012; 45(3): 141-146]http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0zJTVEMTIwMzI3MTU0NV8lMjgxNDEtMTQ2JTI5Qk1CMTEtMjEyLnBkZg==ChrysophanolObesityPhyscionPTP1BRheum undulatum |
| spellingShingle | Woojung Lee Goo Yoon Ye Ran Hwang Yong Kee Kim Su-Nam Kim Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition BMB Reports Chrysophanol Obesity Physcion PTP1B Rheum undulatum |
| title | Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition |
| title_full | Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition |
| title_fullStr | Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition |
| title_full_unstemmed | Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition |
| title_short | Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition |
| title_sort | anti obesity and hypolipidemic effects of rheum undulatum in high fat diet fed c57bl 6 mice through protein tyrosine phosphatase 1b inhibition |
| topic | Chrysophanol Obesity Physcion PTP1B Rheum undulatum |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0zJTVEMTIwMzI3MTU0NV8lMjgxNDEtMTQ2JTI5Qk1CMTEtMjEyLnBkZg== |
| work_keys_str_mv | AT woojunglee antiobesityandhypolipidemiceffectsofrheumundulatuminhighfatdietfedc57bl6micethroughproteintyrosinephosphatase1binhibition AT gooyoon antiobesityandhypolipidemiceffectsofrheumundulatuminhighfatdietfedc57bl6micethroughproteintyrosinephosphatase1binhibition AT yeranhwang antiobesityandhypolipidemiceffectsofrheumundulatuminhighfatdietfedc57bl6micethroughproteintyrosinephosphatase1binhibition AT yongkeekim antiobesityandhypolipidemiceffectsofrheumundulatuminhighfatdietfedc57bl6micethroughproteintyrosinephosphatase1binhibition AT sunamkim antiobesityandhypolipidemiceffectsofrheumundulatuminhighfatdietfedc57bl6micethroughproteintyrosinephosphatase1binhibition |