Deep brain stimulation and neuromodulation for torsion dystonia
<p><strong>Objective</strong> To discuss the curative effect and safety of deep brain stimulation (DBS) and neuromodulation in the treatment of patients with torsion dystonia. <strong>Methods </strong> Ten patients with torsion dystonia underwent subthalamic nucleus...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2015-10-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1286 |
| _version_ | 1818303690557095936 |
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| author | Jing WANG Xin WANG Tian LUO Nan LI Xue-lian WANG Guo-dong GAO |
| author_facet | Jing WANG Xin WANG Tian LUO Nan LI Xue-lian WANG Guo-dong GAO |
| author_sort | Jing WANG |
| collection | DOAJ |
| description | <p><strong>Objective</strong> To discuss the curative effect and safety of deep brain stimulation (DBS) and neuromodulation in the treatment of patients with torsion dystonia. <strong>Methods </strong> Ten patients with torsion dystonia underwent subthalamic nucleus DBS (STN-DBS) and 3 patients with torsion dystonia underwent globus pallidus internus DBS (GPi-DBS). Regulate the stimulus parameters, evaluate the improvement of torsion dystonia by using Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and record related adverse events. <strong>Results </strong> Among the 13 patients, 6 patients were improved by over 60% in 1-3 d and 3 patients one week after stimulation, and the improvement rate was > 75% in 6 months and > 85% in one year. Two patients showed improvement 2 months after stimulation, and the improvement rate was > 60% in 6 months and > 80% in one year. One patient showed slight improvement immediately after operation, and the improvement rate increased to 45% in 6 months and 75% in one year. One patient removed the stimulator. No adverse event related to the operation was found in all 13 patients. The stimulus parameters for STN-DBS were voltage 1.50-2.00 V, frequency 130-145 Hz, pulse width 60-90 μs at 6 months postoperatively, and were voltage 2.00-2.50 V, frequency 130-150 Hz, pulse width 60-90 μs at one year postoperatively. The stimulus parameters for GPi-DBS were voltage 2.50-2.80 V, frequency 130-160 Hz, pulse width 60-90 μs at 6 months postoperatively, and were voltage 2.50-4.00 V, frequency 145-170 Hz, pulse width 60-90 μs at one year postoperatively. <strong>Conclusions</strong> Both STN-DBS and GPi-DBS have good curative effect and safety in the treatment for torsion dystonia. Besides, patients should be treated with individual neuromodulation.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.10.007</p> |
| first_indexed | 2024-12-13T05:58:49Z |
| format | Article |
| id | doaj.art-7b9de51739464d7da7e4970bf64ae554 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-13T05:58:49Z |
| publishDate | 2015-10-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-7b9de51739464d7da7e4970bf64ae5542022-12-21T23:57:23ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312015-10-0115108008031272Deep brain stimulation and neuromodulation for torsion dystoniaJing WANG0Xin WANG1Tian LUO2Nan LI3Xue-lian WANG4Guo-dong GAO5Department of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710038, Shanxi, China<p><strong>Objective</strong> To discuss the curative effect and safety of deep brain stimulation (DBS) and neuromodulation in the treatment of patients with torsion dystonia. <strong>Methods </strong> Ten patients with torsion dystonia underwent subthalamic nucleus DBS (STN-DBS) and 3 patients with torsion dystonia underwent globus pallidus internus DBS (GPi-DBS). Regulate the stimulus parameters, evaluate the improvement of torsion dystonia by using Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and record related adverse events. <strong>Results </strong> Among the 13 patients, 6 patients were improved by over 60% in 1-3 d and 3 patients one week after stimulation, and the improvement rate was > 75% in 6 months and > 85% in one year. Two patients showed improvement 2 months after stimulation, and the improvement rate was > 60% in 6 months and > 80% in one year. One patient showed slight improvement immediately after operation, and the improvement rate increased to 45% in 6 months and 75% in one year. One patient removed the stimulator. No adverse event related to the operation was found in all 13 patients. The stimulus parameters for STN-DBS were voltage 1.50-2.00 V, frequency 130-145 Hz, pulse width 60-90 μs at 6 months postoperatively, and were voltage 2.00-2.50 V, frequency 130-150 Hz, pulse width 60-90 μs at one year postoperatively. The stimulus parameters for GPi-DBS were voltage 2.50-2.80 V, frequency 130-160 Hz, pulse width 60-90 μs at 6 months postoperatively, and were voltage 2.50-4.00 V, frequency 145-170 Hz, pulse width 60-90 μs at one year postoperatively. <strong>Conclusions</strong> Both STN-DBS and GPi-DBS have good curative effect and safety in the treatment for torsion dystonia. Besides, patients should be treated with individual neuromodulation.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.10.007</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1286Dystonia musculorum deformansDeep brain stimulation |
| spellingShingle | Jing WANG Xin WANG Tian LUO Nan LI Xue-lian WANG Guo-dong GAO Deep brain stimulation and neuromodulation for torsion dystonia Chinese Journal of Contemporary Neurology and Neurosurgery Dystonia musculorum deformans Deep brain stimulation |
| title | Deep brain stimulation and neuromodulation for torsion dystonia |
| title_full | Deep brain stimulation and neuromodulation for torsion dystonia |
| title_fullStr | Deep brain stimulation and neuromodulation for torsion dystonia |
| title_full_unstemmed | Deep brain stimulation and neuromodulation for torsion dystonia |
| title_short | Deep brain stimulation and neuromodulation for torsion dystonia |
| title_sort | deep brain stimulation and neuromodulation for torsion dystonia |
| topic | Dystonia musculorum deformans Deep brain stimulation |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1286 |
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