Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps
IntroductionBoth conventional adenoma (AD) and serrated polyp (SP) were known precursor lesions of colorectal cancer (CRC). Modifiable lifestyle factors were significantly associated with CRC risk, but whether these factors were related to the risk of different precursors of CRC needed to be clarifi...
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Frontiers Media S.A.
2024-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1269629/full |
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| author | Jue Xu Peihan Chi Kang Qin Biao Li Zhongxue Cheng Zhecong Yu Caixia Jiang Yunxian Yu |
| author_facet | Jue Xu Peihan Chi Kang Qin Biao Li Zhongxue Cheng Zhecong Yu Caixia Jiang Yunxian Yu |
| author_sort | Jue Xu |
| collection | DOAJ |
| description | IntroductionBoth conventional adenoma (AD) and serrated polyp (SP) were known precursor lesions of colorectal cancer (CRC). Modifiable lifestyle factors were significantly associated with CRC risk, but whether these factors were related to the risk of different precursors of CRC needed to be clarified. This study aimed to evaluate the risks of AD and SP caused by lifestyle factors and compare the risk differences between AD and SP.MethodsThe study population was from the CRC screening cohort in Hangzhou, China. A total of 458,457 eligible individuals volunteered to undergo initial screening including the fecal immunochemical test (FIT) and the CRC risk assessment. Finally, 13,993 participants who had undergone colonoscopy tests and had been diagnosed at designated hospitals were selected in this study. All participants were required to fill out a questionnaire during the initial screening for collecting their information. The generalized estimate equation (GEE) model was used to assess the association between lifestyle factors/dietary preferences and AD/SP.ResultsThe body mass index (BMI) and smoking were positively associated with the risks of only SP (BMI: OR = 1.50, 95%CI: 1.23–1.84; smoking: OR = 1.29, 95%CI: 1.07–1.55), only AD (BMI: OR = 1.53, 95%CI: 1.28–1.82; OR = 1.24, 95%CI: 1.11–1.39), and synchronous SP and AD (BMI: OR = 1.97, 95%CI: 1.40–2.75; smoking: OR = 1.53, 95%CI: 1.27–1.85). In the case-group comparison, smoking was more strongly associated with the risk of synchronous SP and AD than only AD. Alcohol drinking was positively associated with the risk of AD (OR = 1.28, 95%CI: 1.14–1.44), but no statistically significant difference was observed in risks in the case-group comparison. Furthermore, whole-grain intake was associated with a decreased risk of only AD (OR = 0.78, 95%CI: 0.65–0.93). However, white meat intake was positively associated with risks of only SP when compared with AD cases (OR = 1.60, 95%CI: 1.15–2.23).ConclusionThe current study identified common risk factors such as BMI and smoking as well as different risks of certain factors (e.g., alcohol drinking and whole-grain intake) for SP and AD. However, there were still some factors, especially diet-related factors, that have not been fully elucidated in their association with the two lesions. Further research is needed in future to confirm and develop prevention strategies for different lesions. |
| first_indexed | 2024-03-08T14:46:04Z |
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| spelling | doaj.art-7b9eb5ec62cc491288c6315d184c01e02024-01-11T09:50:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-01-011010.3389/fnut.2023.12696291269629Association between lifestyle and dietary preference factors and conventional adenomas and serrated polypsJue Xu0Peihan Chi1Kang Qin2Biao Li3Zhongxue Cheng4Zhecong Yu5Caixia Jiang6Yunxian Yu7HangZhou Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaHangZhou Center for Disease Control and Prevention, Hangzhou, ChinaHangZhou Center for Disease Control and Prevention, Hangzhou, ChinaHangZhou Center for Disease Control and Prevention, Hangzhou, ChinaHangZhou Center for Disease Control and Prevention, Hangzhou, ChinaHangZhou Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaIntroductionBoth conventional adenoma (AD) and serrated polyp (SP) were known precursor lesions of colorectal cancer (CRC). Modifiable lifestyle factors were significantly associated with CRC risk, but whether these factors were related to the risk of different precursors of CRC needed to be clarified. This study aimed to evaluate the risks of AD and SP caused by lifestyle factors and compare the risk differences between AD and SP.MethodsThe study population was from the CRC screening cohort in Hangzhou, China. A total of 458,457 eligible individuals volunteered to undergo initial screening including the fecal immunochemical test (FIT) and the CRC risk assessment. Finally, 13,993 participants who had undergone colonoscopy tests and had been diagnosed at designated hospitals were selected in this study. All participants were required to fill out a questionnaire during the initial screening for collecting their information. The generalized estimate equation (GEE) model was used to assess the association between lifestyle factors/dietary preferences and AD/SP.ResultsThe body mass index (BMI) and smoking were positively associated with the risks of only SP (BMI: OR = 1.50, 95%CI: 1.23–1.84; smoking: OR = 1.29, 95%CI: 1.07–1.55), only AD (BMI: OR = 1.53, 95%CI: 1.28–1.82; OR = 1.24, 95%CI: 1.11–1.39), and synchronous SP and AD (BMI: OR = 1.97, 95%CI: 1.40–2.75; smoking: OR = 1.53, 95%CI: 1.27–1.85). In the case-group comparison, smoking was more strongly associated with the risk of synchronous SP and AD than only AD. Alcohol drinking was positively associated with the risk of AD (OR = 1.28, 95%CI: 1.14–1.44), but no statistically significant difference was observed in risks in the case-group comparison. Furthermore, whole-grain intake was associated with a decreased risk of only AD (OR = 0.78, 95%CI: 0.65–0.93). However, white meat intake was positively associated with risks of only SP when compared with AD cases (OR = 1.60, 95%CI: 1.15–2.23).ConclusionThe current study identified common risk factors such as BMI and smoking as well as different risks of certain factors (e.g., alcohol drinking and whole-grain intake) for SP and AD. However, there were still some factors, especially diet-related factors, that have not been fully elucidated in their association with the two lesions. Further research is needed in future to confirm and develop prevention strategies for different lesions.https://www.frontiersin.org/articles/10.3389/fnut.2023.1269629/fullcolorectal cancerconventional adenomasserrated polypsmodifiable lifestyle factorsdiet |
| spellingShingle | Jue Xu Peihan Chi Kang Qin Biao Li Zhongxue Cheng Zhecong Yu Caixia Jiang Yunxian Yu Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps Frontiers in Nutrition colorectal cancer conventional adenomas serrated polyps modifiable lifestyle factors diet |
| title | Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| title_full | Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| title_fullStr | Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| title_full_unstemmed | Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| title_short | Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| title_sort | association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps |
| topic | colorectal cancer conventional adenomas serrated polyps modifiable lifestyle factors diet |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1269629/full |
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