Oxidative stress and valvular endothelial cells in aortic valve calcification
Calcified aortic valve disease (CAVD) is a common cardiovascular disease in elderly individuals. Although it was previously considered a degenerative disease, it is, in fact, a progressive disease involving multiple mechanisms. Aortic valve endothelial cells, which cover the outermost layer of the a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223005644 |
| _version_ | 1797822121501523968 |
|---|---|
| author | Li Shu Zhen Yuan Fei Li Zhejun Cai |
| author_facet | Li Shu Zhen Yuan Fei Li Zhejun Cai |
| author_sort | Li Shu |
| collection | DOAJ |
| description | Calcified aortic valve disease (CAVD) is a common cardiovascular disease in elderly individuals. Although it was previously considered a degenerative disease, it is, in fact, a progressive disease involving multiple mechanisms. Aortic valve endothelial cells, which cover the outermost layer of the aortic valve and are directly exposed to various pathogenic factors, play a significant role in the onset and progression of CAVD. Hemodynamic changes can directly damage the structure and function of valvular endothelial cells (VECs). This leads to inflammatory infiltration and oxidative stress, which promote the progression of CAVD. VECs can regulate the pathological differentiation of valvular interstitial cells (VICs) through NO and thus affect the process of CAVD. Under the influence of pathological factors, VECs can also be transformed into VICs through EndMT, and then the pathological differentiation of VICs eventually leads to the formation of calcification. This review discusses the role of VECs, especially the role of oxidative stress in VECs, in the process of aortic valve calcification. |
| first_indexed | 2024-03-13T10:03:13Z |
| format | Article |
| id | doaj.art-7b9fd6c0788e4da0a90246326801061d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:13Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7b9fd6c0788e4da0a90246326801061d2023-05-23T04:21:02ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114775Oxidative stress and valvular endothelial cells in aortic valve calcificationLi Shu0Zhen Yuan1Fei Li2Zhejun Cai3Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, ChinaDepartment of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, Hubei, China; Corresponding authors.Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China; Corresponding authors.Calcified aortic valve disease (CAVD) is a common cardiovascular disease in elderly individuals. Although it was previously considered a degenerative disease, it is, in fact, a progressive disease involving multiple mechanisms. Aortic valve endothelial cells, which cover the outermost layer of the aortic valve and are directly exposed to various pathogenic factors, play a significant role in the onset and progression of CAVD. Hemodynamic changes can directly damage the structure and function of valvular endothelial cells (VECs). This leads to inflammatory infiltration and oxidative stress, which promote the progression of CAVD. VECs can regulate the pathological differentiation of valvular interstitial cells (VICs) through NO and thus affect the process of CAVD. Under the influence of pathological factors, VECs can also be transformed into VICs through EndMT, and then the pathological differentiation of VICs eventually leads to the formation of calcification. This review discusses the role of VECs, especially the role of oxidative stress in VECs, in the process of aortic valve calcification.http://www.sciencedirect.com/science/article/pii/S0753332223005644Calcific aortic valve diseaseValvular endothelial cell (VEC)Shear stressEndothelial injuryNOEndothelial to mesenchymal transition (EndMT) |
| spellingShingle | Li Shu Zhen Yuan Fei Li Zhejun Cai Oxidative stress and valvular endothelial cells in aortic valve calcification Biomedicine & Pharmacotherapy Calcific aortic valve disease Valvular endothelial cell (VEC) Shear stress Endothelial injury NO Endothelial to mesenchymal transition (EndMT) |
| title | Oxidative stress and valvular endothelial cells in aortic valve calcification |
| title_full | Oxidative stress and valvular endothelial cells in aortic valve calcification |
| title_fullStr | Oxidative stress and valvular endothelial cells in aortic valve calcification |
| title_full_unstemmed | Oxidative stress and valvular endothelial cells in aortic valve calcification |
| title_short | Oxidative stress and valvular endothelial cells in aortic valve calcification |
| title_sort | oxidative stress and valvular endothelial cells in aortic valve calcification |
| topic | Calcific aortic valve disease Valvular endothelial cell (VEC) Shear stress Endothelial injury NO Endothelial to mesenchymal transition (EndMT) |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223005644 |
| work_keys_str_mv | AT lishu oxidativestressandvalvularendothelialcellsinaorticvalvecalcification AT zhenyuan oxidativestressandvalvularendothelialcellsinaorticvalvecalcification AT feili oxidativestressandvalvularendothelialcellsinaorticvalvecalcification AT zhejuncai oxidativestressandvalvularendothelialcellsinaorticvalvecalcification |