The DNA intercalators ethidium bromide and propidium iodide also bind to core histones

The DNA intercalators ethidium bromide and propidium iodide also bind to core histones

Eukaryotic DNA is compacted in the form of chromatin, in a complex with histones and other non-histone proteins. The intimate association of DNA and histones in chromatin raises the possibility that DNA-interactive small molecules may bind to chromatin-associated proteins such as histones. Employing...

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Bibliographic Details
Main Authors: Amrita Banerjee, Parijat Majumder, Sulagna Sanyal, Jasdeep Singh, Kuladip Jana, Chandrima Das, Dipak Dasgupta
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Chromatin compaction
Histone and DNA binding
DNA release
Histone acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000175

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