Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation

Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation

The interrelationships between periodontal disease, obesity-related hyperlipidemia and mechanical forces and their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex. The PdL serves as a connective tissue between teeth and alveolar b...

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Bibliographic Details
Main Authors: Lisa Schuldt, Michael Reimann, Katrin von Brandenstein, Julia Steinmetz, Annika Döding, Ulrike Schulze-Späte, Collin Jacobs, Judit Symmank
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
periodontitis
tooth movement
obesity
palmitic acid
histone modification
inflammation
Online Access:https://www.mdpi.com/2073-4409/11/6/955

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