Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin
The aim of this paper was to formulate microspheres based on biodegradable polymers (chitosan and sodium alginate), using the complex coacervation technique. Subsequently, the prepared microspheres were loaded with quercetin (QUE), a pharmacological active ingredient insoluble in water and unstable...
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| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/3/490 |
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| author | Olimpia Daniela Frenț Narcis Duteanu Alin Cristian Teusdea Stefania Ciocan Laura Vicaș Tunde Jurca Mariana Muresan Annamaria Pallag Paula Ianasi Eleonora Marian |
| author_facet | Olimpia Daniela Frenț Narcis Duteanu Alin Cristian Teusdea Stefania Ciocan Laura Vicaș Tunde Jurca Mariana Muresan Annamaria Pallag Paula Ianasi Eleonora Marian |
| author_sort | Olimpia Daniela Frenț |
| collection | DOAJ |
| description | The aim of this paper was to formulate microspheres based on biodegradable polymers (chitosan and sodium alginate), using the complex coacervation technique. Subsequently, the prepared microspheres were loaded with quercetin (QUE), a pharmacological active ingredient insoluble in water and unstable to light, temperature and air. After preparation, the loaded microspheres underwent several studies for physical chemical characterization (performed by scanning electron microscopy—SEM, laser 3D scanning, and thermal analysis—TA). Furthermore, they were analyzed in order to obtain information regarding swelling index, drug entrapment, and in vitro release capacity. The obtained experimental data demonstrated 86.07% entrapment of QUE into the microspheres, in the case of the one with the highest Ch concentration. Additionally, it was proved that such systems allow the controlled release of the active drug over 24 h at the intestinal level. SEM micrographs proved that the prepared microspheres have a wrinkled surface, with compact structures and a large number of folds. On the basis of the TA analysis, it was concluded that the obtained microspheres were thermally stable, facilitating their usage at normal physiological temperatures as drug delivery systems. |
| first_indexed | 2024-03-09T23:16:41Z |
| format | Article |
| id | doaj.art-7ba739312e364bf8a479c805436f254f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T23:16:41Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-7ba739312e364bf8a479c805436f254f2023-11-23T17:34:41ZengMDPI AGPolymers2073-43602022-01-0114349010.3390/polym14030490Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with QuercetinOlimpia Daniela Frenț0Narcis Duteanu1Alin Cristian Teusdea2Stefania Ciocan3Laura Vicaș4Tunde Jurca5Mariana Muresan6Annamaria Pallag7Paula Ianasi8Eleonora Marian9Doctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087 Oradea, RomaniaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timisoara, 2 Piata Victoriei, 300006 Timisoara, RomaniaFaculty of Environmental Protection, University of Oradea, 26th Gen. Magheru Avenue, 410087 Oradea, RomaniaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timisoara, 2 Piata Victoriei, 300006 Timisoara, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, RomaniaDepartment of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1th December Square, 410068 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, RomaniaINCEMC-National Institute for Research and Development in Electrochemistry and Condensed Matter—Timisoara, No.144 Dr. A. Paunescu Podeanu Street, 300569 Timisoara, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga Street, 410028 Oradea, RomaniaThe aim of this paper was to formulate microspheres based on biodegradable polymers (chitosan and sodium alginate), using the complex coacervation technique. Subsequently, the prepared microspheres were loaded with quercetin (QUE), a pharmacological active ingredient insoluble in water and unstable to light, temperature and air. After preparation, the loaded microspheres underwent several studies for physical chemical characterization (performed by scanning electron microscopy—SEM, laser 3D scanning, and thermal analysis—TA). Furthermore, they were analyzed in order to obtain information regarding swelling index, drug entrapment, and in vitro release capacity. The obtained experimental data demonstrated 86.07% entrapment of QUE into the microspheres, in the case of the one with the highest Ch concentration. Additionally, it was proved that such systems allow the controlled release of the active drug over 24 h at the intestinal level. SEM micrographs proved that the prepared microspheres have a wrinkled surface, with compact structures and a large number of folds. On the basis of the TA analysis, it was concluded that the obtained microspheres were thermally stable, facilitating their usage at normal physiological temperatures as drug delivery systems.https://www.mdpi.com/2073-4360/14/3/490microspheresbiodegradable polymerscomplex coacervationchitosansodium alginatequercetin |
| spellingShingle | Olimpia Daniela Frenț Narcis Duteanu Alin Cristian Teusdea Stefania Ciocan Laura Vicaș Tunde Jurca Mariana Muresan Annamaria Pallag Paula Ianasi Eleonora Marian Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin Polymers microspheres biodegradable polymers complex coacervation chitosan sodium alginate quercetin |
| title | Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin |
| title_full | Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin |
| title_fullStr | Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin |
| title_full_unstemmed | Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin |
| title_short | Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin |
| title_sort | preparation and characterization of chitosan alginate microspheres loaded with quercetin |
| topic | microspheres biodegradable polymers complex coacervation chitosan sodium alginate quercetin |
| url | https://www.mdpi.com/2073-4360/14/3/490 |
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