The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous d...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/4/1026 |
| _version_ | 1797604673143701504 |
|---|---|
| author | N. M. Liyanage D. P. Nagahawatta Thilina U. Jayawardena You-Jin Jeon |
| author_facet | N. M. Liyanage D. P. Nagahawatta Thilina U. Jayawardena You-Jin Jeon |
| author_sort | N. M. Liyanage |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD’s main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications. |
| first_indexed | 2024-03-11T04:50:04Z |
| format | Article |
| id | doaj.art-7ba7d6cbd9bf4ba79fb2592dd60d7da8 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T04:50:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7ba7d6cbd9bf4ba79fb2592dd60d7da82023-11-17T20:07:07ZengMDPI AGLife2075-17292023-04-01134102610.3390/life13041026The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel DiseaseN. M. Liyanage0D. P. Nagahawatta1Thilina U. Jayawardena2You-Jin Jeon3Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of KoreaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of KoreaInflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD’s main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications.https://www.mdpi.com/2075-1729/13/4/1026seaweedpolysaccharideinflammatory bowel diseasegastrointestinal health |
| spellingShingle | N. M. Liyanage D. P. Nagahawatta Thilina U. Jayawardena You-Jin Jeon The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease Life seaweed polysaccharide inflammatory bowel disease gastrointestinal health |
| title | The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease |
| title_full | The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease |
| title_fullStr | The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease |
| title_full_unstemmed | The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease |
| title_short | The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease |
| title_sort | role of seaweed polysaccharides in gastrointestinal health protective effect against inflammatory bowel disease |
| topic | seaweed polysaccharide inflammatory bowel disease gastrointestinal health |
| url | https://www.mdpi.com/2075-1729/13/4/1026 |
| work_keys_str_mv | AT nmliyanage theroleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT dpnagahawatta theroleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT thilinaujayawardena theroleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT youjinjeon theroleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT nmliyanage roleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT dpnagahawatta roleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT thilinaujayawardena roleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease AT youjinjeon roleofseaweedpolysaccharidesingastrointestinalhealthprotectiveeffectagainstinflammatoryboweldisease |