Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology

Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology

Klebsiella pneumoniae is a Gram-negative pathogen of clinical relevance, which can provoke serious urinary and blood infections and pneumonia. This bacterium is a major public health threat due to its resistance to several antibiotic classes. Using a reverse vaccinology approach, 7 potential antigen...

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Bibliographic Details
Main Authors: Nicola Cuscino, Ayesha Fatima, Vincenzo Di Pilato, Matteo Bulati, Caterina Alfano, Elisa Monaca, Giuseppina Di Mento, Daniele Di Carlo, Francesca Cardinale, Francesco Monaco, Gian Maria Rossolini, Asif M. Khan, Pier Giulio Conaldi, Bruno Douradinha
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Klebsiella pneumoniae
Reverse vaccinology
Antimicrobial resistance
Carbapenems
Subunit vaccine
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003695

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