The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD.
Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucida...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-024-12136-6 |
| _version_ | 1797233533632118784 |
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| author | Mei Xie Jie Gao Xidong Ma Jialin Song Chongchong Wu Yangyu Zhou Tianjiao Jiang Yiran Liang Chen Yang Xinyu Bao Xin Zhang Jie Yao Ying Jing Jianlin Wu Jianxin Wang Xinying Xue |
| author_facet | Mei Xie Jie Gao Xidong Ma Jialin Song Chongchong Wu Yangyu Zhou Tianjiao Jiang Yiran Liang Chen Yang Xinyu Bao Xin Zhang Jie Yao Ying Jing Jianlin Wu Jianxin Wang Xinying Xue |
| author_sort | Mei Xie |
| collection | DOAJ |
| description | Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as subsolid nodules. Materials and methods The inclusion of patients exhibiting clinical staging of IA-IIB subsolid nodules. Clinical information, computed tomography (CT) features before surgical resection and pathological characteristics including tertiary lymphoid structures of the tumors were recorded for further exploration of correlation with EGFR mutation and prognosis. Results Finally, 325 patients were enrolled into this study, with an average age of 56.8 ± 9.8 years. There are 173 patients (53.2%) harboring EGFR mutation. Logistic regression model analysis showed that female (OR = 1.944, p = 0.015), mix ground glass nodule (OR = 2.071, p = 0.003, bubble-like lucency (OR = 1.991, p = 0.003) were significant risk factors of EGFR mutations. Additionally, EGFR mutations were negatively correlated with TLS presence and density. Prognosis analysis showed that the presence of TLS was associated with better recurrence-free survival (RFS)(p = 0.03) while EGFR mutations were associated with worse RFS(p = 0.01). The RFS in patients with TLS was considerably excel those without TLS within EGFR wild type group(p = 0.018). Multivariate analyses confirmed that EGFR mutation was an independent prognostic predictor for RFS (HR = 3.205, p = 0.037). Conclusions In early-phase LUADs, subsolid nodules with EGFR mutation had specific clinical and radiological signatures. EGFR mutation was associated with worse survival outcomes and negatively correlated with TLS, which might weaken the positive impact of TLS on prognosis. Highly attention should be paid to the use of EGFR-TKI for further treatment as agents in early LUAD patients who carrying EGFR mutation. |
| first_indexed | 2024-04-24T16:17:41Z |
| format | Article |
| id | doaj.art-7ba8a568a2ff42499cee89c320a40f81 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T16:17:41Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7ba8a568a2ff42499cee89c320a40f812024-03-31T11:23:16ZengBMCBMC Cancer1471-24072024-03-012411910.1186/s12885-024-12136-6The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD.Mei Xie0Jie Gao1Xidong Ma2Jialin Song3Chongchong Wu4Yangyu Zhou5Tianjiao Jiang6Yiran Liang7Chen Yang8Xinyu Bao9Xin Zhang10Jie Yao11Ying Jing12Jianlin Wu13Jianxin Wang14Xinying Xue15Department of Respiratory and Critical Care, Chinese PLA General Hospital, the First Medical CentreDepartment of Pathology, Chinese PLA General Hospital, the First Medical CentreDepartment of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Respiratory and Critical Care, Weifang Medical CollegeDepartment of Radiology, Chinese PLA General Hospital, the First Medical CentreDepartment of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Radiology, Affiliated Hospital of Qingdao UniversityDepartment of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Laboratory Medicine, Chinese PLA General Hospital, the First Medical CentreDepartment of Respiratory and Critical Care, Weifang Medical CollegeDepartment of Respiratory and Critical Care, Weifang Medical CollegeDepartment of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical UniversityCenter for Intelligent Medicine, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences, Fudan UniversityDepartment of Radiology, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Respiratory and Critical Care, Chinese PLA General Hospital, the First Medical CentreDepartment of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical UniversityAbstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as subsolid nodules. Materials and methods The inclusion of patients exhibiting clinical staging of IA-IIB subsolid nodules. Clinical information, computed tomography (CT) features before surgical resection and pathological characteristics including tertiary lymphoid structures of the tumors were recorded for further exploration of correlation with EGFR mutation and prognosis. Results Finally, 325 patients were enrolled into this study, with an average age of 56.8 ± 9.8 years. There are 173 patients (53.2%) harboring EGFR mutation. Logistic regression model analysis showed that female (OR = 1.944, p = 0.015), mix ground glass nodule (OR = 2.071, p = 0.003, bubble-like lucency (OR = 1.991, p = 0.003) were significant risk factors of EGFR mutations. Additionally, EGFR mutations were negatively correlated with TLS presence and density. Prognosis analysis showed that the presence of TLS was associated with better recurrence-free survival (RFS)(p = 0.03) while EGFR mutations were associated with worse RFS(p = 0.01). The RFS in patients with TLS was considerably excel those without TLS within EGFR wild type group(p = 0.018). Multivariate analyses confirmed that EGFR mutation was an independent prognostic predictor for RFS (HR = 3.205, p = 0.037). Conclusions In early-phase LUADs, subsolid nodules with EGFR mutation had specific clinical and radiological signatures. EGFR mutation was associated with worse survival outcomes and negatively correlated with TLS, which might weaken the positive impact of TLS on prognosis. Highly attention should be paid to the use of EGFR-TKI for further treatment as agents in early LUAD patients who carrying EGFR mutation.https://doi.org/10.1186/s12885-024-12136-6LUADSubsolid noduleEpidermal growth factor receptorTertiary lymphoid structuresComputed tomography |
| spellingShingle | Mei Xie Jie Gao Xidong Ma Jialin Song Chongchong Wu Yangyu Zhou Tianjiao Jiang Yiran Liang Chen Yang Xinyu Bao Xin Zhang Jie Yao Ying Jing Jianlin Wu Jianxin Wang Xinying Xue The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. BMC Cancer LUAD Subsolid nodule Epidermal growth factor receptor Tertiary lymphoid structures Computed tomography |
| title | The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. |
| title_full | The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. |
| title_fullStr | The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. |
| title_full_unstemmed | The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. |
| title_short | The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. |
| title_sort | radiological characteristics tertiary lymphoid structures and survival status associated with egfr mutation in patients with subsolid nodules like stage i ii luad |
| topic | LUAD Subsolid nodule Epidermal growth factor receptor Tertiary lymphoid structures Computed tomography |
| url | https://doi.org/10.1186/s12885-024-12136-6 |
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