A review of herb-induced liver injury in mainland china
Traditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burde...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.813073/full |
| _version_ | 1811241956310777856 |
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| author | Yan Yang Fei-Lin Ge Jin-Fa Tang Shuang-Lin Qin Rui Zeng Meng-Lin Yao Xiao-He Xiao Zhao-Fang Bai Cheng-Lin Tang |
| author_facet | Yan Yang Fei-Lin Ge Jin-Fa Tang Shuang-Lin Qin Rui Zeng Meng-Lin Yao Xiao-He Xiao Zhao-Fang Bai Cheng-Lin Tang |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | Traditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burden, but also consumes medical resources. However, the pharmacoepidemiology and risk factors of HILI are still unclear due to the complexity of herbs (medication theory, drug composition, dual properties of drugs and food, etc.). China is the country with the most extensive use of herbs and cases of HILI worldwide. The safety profile of herbs (especially with respect to HILI) has also affected the use of herbs internationally. Therefore, this review focuses on the epidemic situation of HILI in mainland China to compile its characteristics, while focusing on the three main aspects of patients, drugs, and unreasonable prescriptions to explore the potential risk factors. Our objective was to provide a reference for HILI pharmacovigilance and risk prevention and control and contribute to Chinese knowledge of the realisation of the “Medication without Harm” global safe medication strategic goal of the World Health Organization. |
| first_indexed | 2024-04-12T13:44:53Z |
| format | Article |
| id | doaj.art-7ba93a47a62242e3a7ae32527e9ede3c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T13:44:53Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7ba93a47a62242e3a7ae32527e9ede3c2022-12-22T03:30:44ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.813073813073A review of herb-induced liver injury in mainland chinaYan Yang0Fei-Lin Ge1Jin-Fa Tang2Shuang-Lin Qin3Rui Zeng4Meng-Lin Yao5Xiao-He Xiao6Zhao-Fang Bai7Cheng-Lin Tang8College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, ChinaDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, ChinaSchool of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, ChinaSchool of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, ChinaSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, ChinaTraditional medicines have greatly contributed to people’s health worldwide. However, in recent years, the frequent occurrence of herb-induced liver injury (HILI) has raised public concerns regarding the safety of herbs. HILI not only severely impacts public health, thus increasing its medical burden, but also consumes medical resources. However, the pharmacoepidemiology and risk factors of HILI are still unclear due to the complexity of herbs (medication theory, drug composition, dual properties of drugs and food, etc.). China is the country with the most extensive use of herbs and cases of HILI worldwide. The safety profile of herbs (especially with respect to HILI) has also affected the use of herbs internationally. Therefore, this review focuses on the epidemic situation of HILI in mainland China to compile its characteristics, while focusing on the three main aspects of patients, drugs, and unreasonable prescriptions to explore the potential risk factors. Our objective was to provide a reference for HILI pharmacovigilance and risk prevention and control and contribute to Chinese knowledge of the realisation of the “Medication without Harm” global safe medication strategic goal of the World Health Organization.https://www.frontiersin.org/articles/10.3389/fphar.2022.813073/fullpharmacoepidemiologyrisk factorsrisk prevention and controlherbpharmacovigilance |
| spellingShingle | Yan Yang Fei-Lin Ge Jin-Fa Tang Shuang-Lin Qin Rui Zeng Meng-Lin Yao Xiao-He Xiao Zhao-Fang Bai Cheng-Lin Tang A review of herb-induced liver injury in mainland china Frontiers in Pharmacology pharmacoepidemiology risk factors risk prevention and control herb pharmacovigilance |
| title | A review of herb-induced liver injury in mainland china |
| title_full | A review of herb-induced liver injury in mainland china |
| title_fullStr | A review of herb-induced liver injury in mainland china |
| title_full_unstemmed | A review of herb-induced liver injury in mainland china |
| title_short | A review of herb-induced liver injury in mainland china |
| title_sort | review of herb induced liver injury in mainland china |
| topic | pharmacoepidemiology risk factors risk prevention and control herb pharmacovigilance |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.813073/full |
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