Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved]
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with an as-yet-undefined etiology. The management of CRS has historically been phenotypically driven, and the presence or absence of nasal polyps has frequently guided diagnosis, prognosis, and treatment algorithms. Research over t...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-12-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1909/v1 |
| _version_ | 1828978138685636608 |
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| author | Eric F. Succar Justin H. Turner |
| author_facet | Eric F. Succar Justin H. Turner |
| author_sort | Eric F. Succar |
| collection | DOAJ |
| description | Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with an as-yet-undefined etiology. The management of CRS has historically been phenotypically driven, and the presence or absence of nasal polyps has frequently guided diagnosis, prognosis, and treatment algorithms. Research over the last decade has begun to question the role of this distinction in disease management, and renewed attention has been placed on molecular and cellular endotyping and a more personalized approach to care. Current research exploring immunologic mechanisms, inflammatory endotypes, and molecular biomarkers has the potential to more effectively delineate distinct and clinically relevant subgroups of CRS. The focus of this review will be to discuss and summarize the endotypic characterization of CRS and the potential diagnostic and therapeutic implications of this approach to disease management. |
| first_indexed | 2024-12-14T15:12:16Z |
| format | Article |
| id | doaj.art-7baca9b731fa43a4ac974832799b91fe |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-14T15:12:16Z |
| publishDate | 2018-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7baca9b731fa43a4ac974832799b91fe2022-12-21T22:56:30ZengF1000 Research LtdF1000Research2046-14022018-12-01710.12688/f1000research.16222.117716Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved]Eric F. Succar0Justin H. Turner1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USADepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USAChronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with an as-yet-undefined etiology. The management of CRS has historically been phenotypically driven, and the presence or absence of nasal polyps has frequently guided diagnosis, prognosis, and treatment algorithms. Research over the last decade has begun to question the role of this distinction in disease management, and renewed attention has been placed on molecular and cellular endotyping and a more personalized approach to care. Current research exploring immunologic mechanisms, inflammatory endotypes, and molecular biomarkers has the potential to more effectively delineate distinct and clinically relevant subgroups of CRS. The focus of this review will be to discuss and summarize the endotypic characterization of CRS and the potential diagnostic and therapeutic implications of this approach to disease management.https://f1000research.com/articles/7-1909/v1 |
| spellingShingle | Eric F. Succar Justin H. Turner Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] F1000Research |
| title | Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] |
| title_full | Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] |
| title_short | Recent advances in understanding chronic rhinosinusitis endotypes [version 1; referees: 2 approved] |
| title_sort | recent advances in understanding chronic rhinosinusitis endotypes version 1 referees 2 approved |
| url | https://f1000research.com/articles/7-1909/v1 |
| work_keys_str_mv | AT ericfsuccar recentadvancesinunderstandingchronicrhinosinusitisendotypesversion1referees2approved AT justinhturner recentadvancesinunderstandingchronicrhinosinusitisendotypesversion1referees2approved |