In Vitro 3D Spheroid Culture System Displays Sustained T Cell-dependent CLL Proliferation and Survival

In Vitro 3D Spheroid Culture System Displays Sustained T Cell-dependent CLL Proliferation and Survival

Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironmental cells and signals. The lymph node (LN) is the critical site of in vivo CLL proliferation and development of resistance to both chemotherapy and targeted agents. We present a new model that incorporates key aspects of...

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Bibliographic Details
Main Authors: Marco V. Haselager, Bianca F. van Driel, Eduard Perelaer, Dennis de Rooij, Danial Lashgari, Remco Loos, Arnon P. Kater, Perry D. Moerland, Eric Eldering
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000938

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