Enhancing the Detection of Brucella-Specific CD4+ T Cell Responses in Cattle via in vitro Antigenic Expansion and Restimulation

Enhancing the Detection of Brucella-Specific CD4+ T Cell Responses in Cattle via in vitro Antigenic Expansion and Restimulation

Bovine brucellosis, cause by infection with Brucella abortus, causes reproductive failure in cattle, has a major economic impact to producers, and as a zoonoses, it is a disease of public health concern. Characterization of the protective immune response against Brucella infection is important to ou...

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Bibliographic Details
Main Authors: Paola M. Boggiatto, Robert G. Schaut, Steven C. Olsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
Brucella
proliferation
IFN-γ
antigenic expansion
T cell responses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01944/full

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