Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study
Although diuretics are often prescribed to control fluid overload, they can change Chronic kidney disease-mineral and bone disorder (CKD-MBD) parameters. Previous studies have shown an association between diuretic prescription and changes in both calciuria and parathormone levels. However, the causa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Bone Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187221000012 |
| _version_ | 1818430942133354496 |
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| author | Raquel F.V. Vasco Liliam Takayama Rosa M.R. Pereira Rosa M.A. Moyses Rosilene M. Elias |
| author_facet | Raquel F.V. Vasco Liliam Takayama Rosa M.R. Pereira Rosa M.A. Moyses Rosilene M. Elias |
| author_sort | Raquel F.V. Vasco |
| collection | DOAJ |
| description | Although diuretics are often prescribed to control fluid overload, they can change Chronic kidney disease-mineral and bone disorder (CKD-MBD) parameters. Previous studies have shown an association between diuretic prescription and changes in both calciuria and parathormone levels. However, the causal relationship could not be confirmed. In addition, the effects of diuretics on bone mineral density and turnover markers are yet to be established. To evaluate the effects of diuretics on CKD-MBD, we have performed a prospective randomized trial comparing hydrochlorothiazide with furosemide in a stage 3CKD population followed for 1 year. Furosemide increased bone remodeling and parathormone levels, whereas hydrochlorothiazide attenuated parathyroid hormone rise and decreased bone turnover markers. |
| first_indexed | 2024-12-14T15:41:25Z |
| format | Article |
| id | doaj.art-7bae52a6f6a543c8b4896ebf8516bbc4 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-14T15:41:25Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-7bae52a6f6a543c8b4896ebf8516bbc42022-12-21T22:55:36ZengElsevierBone Reports2352-18722021-06-0114100746Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized studyRaquel F.V. Vasco0Liliam Takayama1Rosa M.R. Pereira2Rosa M.A. Moyses3Rosilene M. Elias4Department of Medicine, Renal Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Corresponding author at: Faculdade de Medicina da Universidade de São Paulo, Serviço de Nefrologia, Rua Dr. Enéas de Carvalho Aguiar 255, 7° andar, São Paulo CEP 05403-000, SP, Brazil.Department of Medicine, Rheumatology Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BrazilDepartment of Medicine, Rheumatology Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BrazilDepartment of Medicine, Renal Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BrazilDepartment of Medicine, Renal Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Universidade Nove de Julho, UNINOVE, São Paulo, BrazilAlthough diuretics are often prescribed to control fluid overload, they can change Chronic kidney disease-mineral and bone disorder (CKD-MBD) parameters. Previous studies have shown an association between diuretic prescription and changes in both calciuria and parathormone levels. However, the causal relationship could not be confirmed. In addition, the effects of diuretics on bone mineral density and turnover markers are yet to be established. To evaluate the effects of diuretics on CKD-MBD, we have performed a prospective randomized trial comparing hydrochlorothiazide with furosemide in a stage 3CKD population followed for 1 year. Furosemide increased bone remodeling and parathormone levels, whereas hydrochlorothiazide attenuated parathyroid hormone rise and decreased bone turnover markers.http://www.sciencedirect.com/science/article/pii/S2352187221000012Calciuria, mineral metabolismBone turnover markersParathyroid hormoneFurosemideHydrochlorothiazide |
| spellingShingle | Raquel F.V. Vasco Liliam Takayama Rosa M.R. Pereira Rosa M.A. Moyses Rosilene M. Elias Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study Bone Reports Calciuria, mineral metabolism Bone turnover markers Parathyroid hormone Furosemide Hydrochlorothiazide |
| title | Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study |
| title_full | Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study |
| title_fullStr | Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study |
| title_full_unstemmed | Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study |
| title_short | Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study |
| title_sort | effects of diuretics furosemide and hydrochlorothiazide on ckd mbd a prospective randomized study |
| topic | Calciuria, mineral metabolism Bone turnover markers Parathyroid hormone Furosemide Hydrochlorothiazide |
| url | http://www.sciencedirect.com/science/article/pii/S2352187221000012 |
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