Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness
The temporal trajectories and neural mechanisms of recovery of cognitive function after a major perturbation of consciousness is of both clinical and neuroscientific interest. The purpose of the present study was to investigate network-level changes in functional brain connectivity associated with t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.706693/full |
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| author | Alexander Rokos Bratislav Mišić Kathleen Berkun Catherine Duclos Vijay Tarnal Ellen Janke Paul Picton Goodarz Golmirzaie Mathias Basner Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes |
| author_facet | Alexander Rokos Bratislav Mišić Kathleen Berkun Catherine Duclos Vijay Tarnal Ellen Janke Paul Picton Goodarz Golmirzaie Mathias Basner Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes |
| author_sort | Alexander Rokos |
| collection | DOAJ |
| description | The temporal trajectories and neural mechanisms of recovery of cognitive function after a major perturbation of consciousness is of both clinical and neuroscientific interest. The purpose of the present study was to investigate network-level changes in functional brain connectivity associated with the recovery and return of six cognitive functions after general anesthesia. High-density electroencephalograms (EEG) were recorded from healthy volunteers undergoing a clinically relevant anesthesia protocol (propofol induction and isoflurane maintenance), and age-matched healthy controls. A battery of cognitive tests (motor praxis, visual object learning test, fractal-2-back, abstract matching, psychomotor vigilance test, digital symbol substitution test) was administered at baseline, upon recovery of consciousness (ROC), and at half-hour intervals up to 3 h following ROC. EEG networks were derived using the strength of functional connectivity measured through the weighted phase lag index (wPLI). A partial least squares (PLS) analysis was conducted to assess changes in these networks: (1) between anesthesia and control groups; (2) during the 3-h recovery from anesthesia; and (3) for each cognitive test during recovery from anesthesia. Networks were maximally perturbed upon ROC but returned to baseline 30–60 min following ROC, despite deficits in cognitive performance that persisted up to 3 h following ROC. Additionally, during recovery from anesthesia, cognitive tests conducted at the same time-point activated distinct and dissociable functional connectivity networks across all frequency bands. The results highlight that the return of cognitive function after anesthetic-induced unconsciousness is task-specific, with unique behavioral and brain network trajectories of recovery. |
| first_indexed | 2024-12-13T20:55:27Z |
| format | Article |
| id | doaj.art-7bb16e6bb5a74e078275a79b54d40d83 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T20:55:27Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-7bb16e6bb5a74e078275a79b54d40d832022-12-21T23:31:45ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-09-011510.3389/fnhum.2021.706693706693Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced UnconsciousnessAlexander Rokos0Bratislav Mišić1Kathleen Berkun2Catherine Duclos3Vijay Tarnal4Ellen Janke5Paul Picton6Goodarz Golmirzaie7Mathias Basner8Michael S. Avidan9Max B. Kelz10George A. Mashour11Stefanie Blain-Moraes12Integrated Program in Neuroscience, McGill University, Montreal, QC, CanadaNeurology and Neurosurgery, McGill University, Montreal, QC, CanadaCognitive Science, McGill University, Montreal, QC, CanadaSchool of Physical and Occupational Therapy, McGill University, Montreal, QC, CanadaDepartment of Anesthesiology, Center of Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United StatesDepartment of Anesthesiology, Center of Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United StatesDepartment of Anesthesiology, Center of Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United StatesDepartment of Anesthesiology, Center of Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United StatesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, WA, United StatesDeparment of Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Anesthesiology, Center of Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United StatesSchool of Physical and Occupational Therapy, McGill University, Montreal, QC, CanadaThe temporal trajectories and neural mechanisms of recovery of cognitive function after a major perturbation of consciousness is of both clinical and neuroscientific interest. The purpose of the present study was to investigate network-level changes in functional brain connectivity associated with the recovery and return of six cognitive functions after general anesthesia. High-density electroencephalograms (EEG) were recorded from healthy volunteers undergoing a clinically relevant anesthesia protocol (propofol induction and isoflurane maintenance), and age-matched healthy controls. A battery of cognitive tests (motor praxis, visual object learning test, fractal-2-back, abstract matching, psychomotor vigilance test, digital symbol substitution test) was administered at baseline, upon recovery of consciousness (ROC), and at half-hour intervals up to 3 h following ROC. EEG networks were derived using the strength of functional connectivity measured through the weighted phase lag index (wPLI). A partial least squares (PLS) analysis was conducted to assess changes in these networks: (1) between anesthesia and control groups; (2) during the 3-h recovery from anesthesia; and (3) for each cognitive test during recovery from anesthesia. Networks were maximally perturbed upon ROC but returned to baseline 30–60 min following ROC, despite deficits in cognitive performance that persisted up to 3 h following ROC. Additionally, during recovery from anesthesia, cognitive tests conducted at the same time-point activated distinct and dissociable functional connectivity networks across all frequency bands. The results highlight that the return of cognitive function after anesthetic-induced unconsciousness is task-specific, with unique behavioral and brain network trajectories of recovery.https://www.frontiersin.org/articles/10.3389/fnhum.2021.706693/fullbrain networksfunctional connectivityelectroencephalographycognitive functionanesthesiapartial least squares |
| spellingShingle | Alexander Rokos Bratislav Mišić Kathleen Berkun Catherine Duclos Vijay Tarnal Ellen Janke Paul Picton Goodarz Golmirzaie Mathias Basner Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness Frontiers in Human Neuroscience brain networks functional connectivity electroencephalography cognitive function anesthesia partial least squares |
| title | Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness |
| title_full | Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness |
| title_fullStr | Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness |
| title_full_unstemmed | Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness |
| title_short | Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness |
| title_sort | distinct and dissociable eeg networks are associated with recovery of cognitive function following anesthesia induced unconsciousness |
| topic | brain networks functional connectivity electroencephalography cognitive function anesthesia partial least squares |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.706693/full |
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