Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation

Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation

Hypoxia is a key feature of tumor microenvironment that contributes to the development of breast cancer stem cells (BCSCs) with strong self-renewal properties. However, the specific mechanism underlying hypoxia in BCSC induction is not completely understood. Herein, we provide evidence that a novel...

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Bibliographic Details
Main Authors: Ming Xu, Xiaoqi Liu, Xinyue Zhou, Yilu Qin, Liping Yang, Siyang Wen, Yuxiang Qiu, Shanchun Chen, Rui Tang, Yuetong Guo, Manran Liu, Yan Sun
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Pharmacological Research
Subjects:
Breast cancer
CircSTT3A
PGK1
Serine metabolism
Chemotherapy resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003201

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