Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines
In the present work, a series of novel pyrido bearing a fused piperazine ring derivatives has been synthesized via suzuki and acid–amine coupling reactions. The synthesized compounds were screened for their in vitro cytotoxic activity against nine different cancer cell lines such as U-251, Panc-1, M...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623004642 |
| _version_ | 1797398632943583232 |
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| author | Jignesh B. Timaniya Paranjay H. Parikh Mrugesh J. Patel Kaushal P. Patel |
| author_facet | Jignesh B. Timaniya Paranjay H. Parikh Mrugesh J. Patel Kaushal P. Patel |
| author_sort | Jignesh B. Timaniya |
| collection | DOAJ |
| description | In the present work, a series of novel pyrido bearing a fused piperazine ring derivatives has been synthesized via suzuki and acid–amine coupling reactions. The synthesized compounds were screened for their in vitro cytotoxic activity against nine different cancer cell lines such as U-251, Panc-1, MCF-7, HepG2, DU-145, A549, 786-O, OVCAR3 and HCT-116. Synthesized compound also screened under normal cell lines like human lungs normal cell line (WI38) and Mouse embryonic normal cell line (NIH3T3) to evaluate safety of synthesized compounds. The bioassay results indicates that synthesized compounds (cpd-S10, cpd-12, cpd-19, cpd-32, cpd-33, cpd-36 and cpd-38) to be moderately effective towards various cancer cell lines (DU-145, PanC1, MCF7, U-251, HCT-116, 786-O, HepG2, A549, OVCAR-3) in the in vitro testing. |
| first_indexed | 2024-03-09T01:28:22Z |
| format | Article |
| id | doaj.art-7bb4468340b948cc9c40a8bed77843ff |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T01:28:22Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-7bb4468340b948cc9c40a8bed77843ff2023-12-10T06:15:41ZengElsevierResults in Chemistry2211-71562023-12-016101225Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell linesJignesh B. Timaniya0Paranjay H. Parikh1Mrugesh J. Patel2Kaushal P. Patel3Department of Advanced Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat 388421, IndiaDepartment of Advanced Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat 388421, IndiaDepartment of Advanced Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat 388421, IndiaDepartment of Advanced Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat 388421, India; Corresponding author at: Department of Advanced Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat 388421, India.In the present work, a series of novel pyrido bearing a fused piperazine ring derivatives has been synthesized via suzuki and acid–amine coupling reactions. The synthesized compounds were screened for their in vitro cytotoxic activity against nine different cancer cell lines such as U-251, Panc-1, MCF-7, HepG2, DU-145, A549, 786-O, OVCAR3 and HCT-116. Synthesized compound also screened under normal cell lines like human lungs normal cell line (WI38) and Mouse embryonic normal cell line (NIH3T3) to evaluate safety of synthesized compounds. The bioassay results indicates that synthesized compounds (cpd-S10, cpd-12, cpd-19, cpd-32, cpd-33, cpd-36 and cpd-38) to be moderately effective towards various cancer cell lines (DU-145, PanC1, MCF7, U-251, HCT-116, 786-O, HepG2, A549, OVCAR-3) in the in vitro testing.http://www.sciencedirect.com/science/article/pii/S2211715623004642PyridoPyrimido piperazineAnticancer |
| spellingShingle | Jignesh B. Timaniya Paranjay H. Parikh Mrugesh J. Patel Kaushal P. Patel Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines Results in Chemistry Pyrido Pyrimido piperazine Anticancer |
| title | Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines |
| title_full | Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines |
| title_fullStr | Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines |
| title_full_unstemmed | Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines |
| title_short | Design, synthesis and evaluation of novel pyrido fused piperazine derivatives: In vitro cytotoxicity study over various cancer cell lines |
| title_sort | design synthesis and evaluation of novel pyrido fused piperazine derivatives in vitro cytotoxicity study over various cancer cell lines |
| topic | Pyrido Pyrimido piperazine Anticancer |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623004642 |
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