Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study
Abstract Objectives Warfarin, like many other anticoagulants, has been linked to an elevated risk of bleeding proportional to the amount of anticoagulation used. Not only was the incidence of bleeding raised by the dosage, but the subtherapeutic international normalized ratio (INR) was also associat...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-023-06383-2 |
| _version_ | 1797801577634856960 |
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| author | Benyapha Sombat Sarisa Tongkaew Aticha Nilwaranon Mathirut Mungthin Kanlaya Jongcherdchootrakul Teeraboon Lertwanichwattana |
| author_facet | Benyapha Sombat Sarisa Tongkaew Aticha Nilwaranon Mathirut Mungthin Kanlaya Jongcherdchootrakul Teeraboon Lertwanichwattana |
| author_sort | Benyapha Sombat |
| collection | DOAJ |
| description | Abstract Objectives Warfarin, like many other anticoagulants, has been linked to an elevated risk of bleeding proportional to the amount of anticoagulation used. Not only was the incidence of bleeding raised by the dosage, but the subtherapeutic international normalized ratio (INR) was also associated with increased thrombotic events. This retrospective cohort and multi-center study evaluated the incidence and risk factors of warfarin therapy complications in community hospitals in Thailand’s central and eastern regions from 2016 to 2021. Results Among 335 patients (683.90 person-year of follow-up), The incidence rate of warfarin complications was 4.91 events per 100 person-year. The independent factor associated with warfarin therapy complications was propranolol prescription (Adjusted RR: 2.29, 95%CI: 1.12–4.71). The secondary analysis was divided according to the outcome of the major bleeding and thromboembolic event. Major bleeding events, hypertension (Adjusted RR: 0.40, 95%CI: 0.17–0.95), amiodarone prescription (Adjusted RR: 5.11, 95%CI: 1.08–24.15), and propranolol prescription (Adjusted RR: 2.86, 95%CI: 1.19–6.83) were the independent risk factors. While in the major thrombotic event, non-steroidal anti-inflammatory drugs (NSAIDs) prescription was an independent factor (Adjusted RR: 10.65, 95%CI: 1.26–90.35). |
| first_indexed | 2024-03-13T04:52:52Z |
| format | Article |
| id | doaj.art-7bb496fb668740939b3664004eb7ab51 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-03-13T04:52:52Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-7bb496fb668740939b3664004eb7ab512023-06-18T11:05:46ZengBMCBMC Research Notes1756-05002023-06-011611810.1186/s13104-023-06383-2Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort studyBenyapha Sombat0Sarisa Tongkaew1Aticha Nilwaranon2Mathirut Mungthin3Kanlaya Jongcherdchootrakul4Teeraboon Lertwanichwattana5Phramongkutklao College of MedicinePhramongkutklao College of MedicinePhramongkutklao College of MedicineDepartment of Parasitology, Phramongkutklao college of medicineDepartment of Military and Community Medicine, Phramongkutklao college of medicineDepartment of Military and Community Medicine, Phramongkutklao college of medicineAbstract Objectives Warfarin, like many other anticoagulants, has been linked to an elevated risk of bleeding proportional to the amount of anticoagulation used. Not only was the incidence of bleeding raised by the dosage, but the subtherapeutic international normalized ratio (INR) was also associated with increased thrombotic events. This retrospective cohort and multi-center study evaluated the incidence and risk factors of warfarin therapy complications in community hospitals in Thailand’s central and eastern regions from 2016 to 2021. Results Among 335 patients (683.90 person-year of follow-up), The incidence rate of warfarin complications was 4.91 events per 100 person-year. The independent factor associated with warfarin therapy complications was propranolol prescription (Adjusted RR: 2.29, 95%CI: 1.12–4.71). The secondary analysis was divided according to the outcome of the major bleeding and thromboembolic event. Major bleeding events, hypertension (Adjusted RR: 0.40, 95%CI: 0.17–0.95), amiodarone prescription (Adjusted RR: 5.11, 95%CI: 1.08–24.15), and propranolol prescription (Adjusted RR: 2.86, 95%CI: 1.19–6.83) were the independent risk factors. While in the major thrombotic event, non-steroidal anti-inflammatory drugs (NSAIDs) prescription was an independent factor (Adjusted RR: 10.65, 95%CI: 1.26–90.35).https://doi.org/10.1186/s13104-023-06383-2WarfarinMajor bleedingThromboembolismINR |
| spellingShingle | Benyapha Sombat Sarisa Tongkaew Aticha Nilwaranon Mathirut Mungthin Kanlaya Jongcherdchootrakul Teeraboon Lertwanichwattana Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study BMC Research Notes Warfarin Major bleeding Thromboembolism INR |
| title | Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study |
| title_full | Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study |
| title_fullStr | Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study |
| title_full_unstemmed | Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study |
| title_short | Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study |
| title_sort | incidence and risk factors of warfarin therapy complications in community hospitals central and eastern regions thailand a retrospective multicenter cohort study |
| topic | Warfarin Major bleeding Thromboembolism INR |
| url | https://doi.org/10.1186/s13104-023-06383-2 |
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