Heritability of Subcortical Grey Matter Structures
<i>Background and Objectives</i>: Subcortical grey matter structures play essential roles in cognitive, affective, social, and motoric functions in humans. Their volume changes with age, and decreased volumes have been linked with many neuropsychiatric disorders. The aim of our study was...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/11/1687 |
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| author | David Strelnikov Amirreza Alijanpourotaghsara Marton Piroska Laszlo Szalontai Bianka Forgo Zsofia Jokkel Alíz Persely Anita Hernyes Lajos Rudolf Kozak Adam Szabo Pal Maurovich-Horvat David Laszlo Tarnoki Adam Domonkos Tarnoki |
| author_facet | David Strelnikov Amirreza Alijanpourotaghsara Marton Piroska Laszlo Szalontai Bianka Forgo Zsofia Jokkel Alíz Persely Anita Hernyes Lajos Rudolf Kozak Adam Szabo Pal Maurovich-Horvat David Laszlo Tarnoki Adam Domonkos Tarnoki |
| author_sort | David Strelnikov |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Subcortical grey matter structures play essential roles in cognitive, affective, social, and motoric functions in humans. Their volume changes with age, and decreased volumes have been linked with many neuropsychiatric disorders. The aim of our study was to examine the heritability of six subcortical brain volumes (the amygdala, caudate nucleus, pallidum, putamen, thalamus, and nucleus accumbens) and four general brain volumes (the total intra-cranial volume and the grey matter, white matter, and cerebrospinal fluid (CSF) volume) in twins. <i>Materials and Methods</i>: A total of 118 healthy adult twins from the Hungarian Twin Registry (86 monozygotic and 32 dizygotic; median age 50 ± 27 years) underwent brain magnetic resonance imaging. Two automated volumetry pipelines, Computational Anatomy Toolbox 12 (CAT12) and volBrain, were used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Age- and sex-adjusted monozygotic and dizygotic intra-pair correlations were calculated, and the univariate ACE model was applied. Pearson’s correlation test was used to compare the results obtained by the two pipelines. <i>Results</i>: The age- and sex-adjusted heritability estimates, using CAT12 for the amygdala, caudate nucleus, pallidum, putamen, and nucleus accumbens, were between 0.75 and 0.95. The thalamus volume was more strongly influenced by common environmental factors (C = 0.45−0.73). The heritability estimates, using volBrain, were between 0.69 and 0.92 for the nucleus accumbens, pallidum, putamen, right amygdala, and caudate nucleus. The left amygdala and thalamus were more strongly influenced by common environmental factors (C = 0.72−0.85). A strong correlation between CAT12 and volBrain (r = 0.74−0.94) was obtained for all volumes. <i>Conclusions</i>: The majority of examined subcortical volumes appeared to be strongly heritable. The thalamus was more strongly influenced by common environmental factors when investigated with both segmentation methods. Our results underline the importance of identifying the relevant genes responsible for variations in the subcortical structure volume and associated diseases. |
| first_indexed | 2024-03-09T18:09:57Z |
| format | Article |
| id | doaj.art-7bb580d0873142af829f7ca4712dcd45 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T18:09:57Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-7bb580d0873142af829f7ca4712dcd452023-11-24T09:12:00ZengMDPI AGMedicina1010-660X1648-91442022-11-015811168710.3390/medicina58111687Heritability of Subcortical Grey Matter StructuresDavid Strelnikov0Amirreza Alijanpourotaghsara1Marton Piroska2Laszlo Szalontai3Bianka Forgo4Zsofia Jokkel5Alíz Persely6Anita Hernyes7Lajos Rudolf Kozak8Adam Szabo9Pal Maurovich-Horvat10David Laszlo Tarnoki11Adam Domonkos Tarnoki12Medical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryDepartment of Radiology, Faculty of Medicine and Health, Örebro University, 702 81 Örebro, SwedenMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary<i>Background and Objectives</i>: Subcortical grey matter structures play essential roles in cognitive, affective, social, and motoric functions in humans. Their volume changes with age, and decreased volumes have been linked with many neuropsychiatric disorders. The aim of our study was to examine the heritability of six subcortical brain volumes (the amygdala, caudate nucleus, pallidum, putamen, thalamus, and nucleus accumbens) and four general brain volumes (the total intra-cranial volume and the grey matter, white matter, and cerebrospinal fluid (CSF) volume) in twins. <i>Materials and Methods</i>: A total of 118 healthy adult twins from the Hungarian Twin Registry (86 monozygotic and 32 dizygotic; median age 50 ± 27 years) underwent brain magnetic resonance imaging. Two automated volumetry pipelines, Computational Anatomy Toolbox 12 (CAT12) and volBrain, were used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Age- and sex-adjusted monozygotic and dizygotic intra-pair correlations were calculated, and the univariate ACE model was applied. Pearson’s correlation test was used to compare the results obtained by the two pipelines. <i>Results</i>: The age- and sex-adjusted heritability estimates, using CAT12 for the amygdala, caudate nucleus, pallidum, putamen, and nucleus accumbens, were between 0.75 and 0.95. The thalamus volume was more strongly influenced by common environmental factors (C = 0.45−0.73). The heritability estimates, using volBrain, were between 0.69 and 0.92 for the nucleus accumbens, pallidum, putamen, right amygdala, and caudate nucleus. The left amygdala and thalamus were more strongly influenced by common environmental factors (C = 0.72−0.85). A strong correlation between CAT12 and volBrain (r = 0.74−0.94) was obtained for all volumes. <i>Conclusions</i>: The majority of examined subcortical volumes appeared to be strongly heritable. The thalamus was more strongly influenced by common environmental factors when investigated with both segmentation methods. Our results underline the importance of identifying the relevant genes responsible for variations in the subcortical structure volume and associated diseases.https://www.mdpi.com/1648-9144/58/11/1687subcorticalvolumetrytwinsheritabilityMRICAT12 |
| spellingShingle | David Strelnikov Amirreza Alijanpourotaghsara Marton Piroska Laszlo Szalontai Bianka Forgo Zsofia Jokkel Alíz Persely Anita Hernyes Lajos Rudolf Kozak Adam Szabo Pal Maurovich-Horvat David Laszlo Tarnoki Adam Domonkos Tarnoki Heritability of Subcortical Grey Matter Structures Medicina subcortical volumetry twins heritability MRI CAT12 |
| title | Heritability of Subcortical Grey Matter Structures |
| title_full | Heritability of Subcortical Grey Matter Structures |
| title_fullStr | Heritability of Subcortical Grey Matter Structures |
| title_full_unstemmed | Heritability of Subcortical Grey Matter Structures |
| title_short | Heritability of Subcortical Grey Matter Structures |
| title_sort | heritability of subcortical grey matter structures |
| topic | subcortical volumetry twins heritability MRI CAT12 |
| url | https://www.mdpi.com/1648-9144/58/11/1687 |
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