Spinal infection caused by Coxiella burnetii
Abstract Background Spinal infection caused by Coxiella burnetii is rare and difficult to diagnose. Here we reported a case of spinal infection from Coxiella burnetii detected by the metagenomic next-generation sequencing (mNGS). Case presentation A 66-year-old male farmer with no medical history re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07938-7 |
| _version_ | 1828069747850215424 |
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| author | Sumin Yang Bai Xue Xiaowen Hu Weidong Zhou Minglei Zhang Mingwei Zhao |
| author_facet | Sumin Yang Bai Xue Xiaowen Hu Weidong Zhou Minglei Zhang Mingwei Zhao |
| author_sort | Sumin Yang |
| collection | DOAJ |
| description | Abstract Background Spinal infection caused by Coxiella burnetii is rare and difficult to diagnose. Here we reported a case of spinal infection from Coxiella burnetii detected by the metagenomic next-generation sequencing (mNGS). Case presentation A 66-year-old male farmer with no medical history reported severe sharp low back pain, numbness and lower limb weakness for three years. Magnetic resonance imaging (MRI) revealed bone destruction and spinal cord compression within L1 and L2. mNGS testing showed that the inspected specimen collected from spinal lesion was detected positively for Coxiella burnetii. After receiving the combined treatment of antibiotic therapy and surgical intervention, the patient recovered well, and the sagittal MRI showed that vertebral edema signals disappeared and the graft of bone fused 16 months after surgery. Conclusion The mNGS may be benefit for early diagnosis and intervention of non-specific spinal infection, and future studies should validate its effectiveness for clinical use in spinal infections. Additionally, antibiotic therapy combined with surgical intervention plays an important role on the treatment of spinal infection caused by Coxiella burnetii. |
| first_indexed | 2024-04-11T00:24:05Z |
| format | Article |
| id | doaj.art-7bb633afbf8f4be3aaa065dcc6e3200c |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-11T00:24:05Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-7bb633afbf8f4be3aaa065dcc6e3200c2023-01-08T12:05:48ZengBMCBMC Infectious Diseases1471-23342023-01-012311510.1186/s12879-022-07938-7Spinal infection caused by Coxiella burnetiiSumin Yang0Bai Xue1Xiaowen Hu2Weidong Zhou3Minglei Zhang4Mingwei Zhao5Department of Orthopedics, Qingdao Chest HospitalQingdao Municipal Centre for Disease Control and Prevention, Qingdao Institute of Prevention MedicineQingdao Municipal Centre for Disease Control and Prevention, Qingdao Institute of Prevention MedicineDepartment of Orthopedics, Qingdao Chest HospitalDepartment of Orthopedics, Qingdao Chest HospitalDepartment of Orthopedics, Qingdao Chest HospitalAbstract Background Spinal infection caused by Coxiella burnetii is rare and difficult to diagnose. Here we reported a case of spinal infection from Coxiella burnetii detected by the metagenomic next-generation sequencing (mNGS). Case presentation A 66-year-old male farmer with no medical history reported severe sharp low back pain, numbness and lower limb weakness for three years. Magnetic resonance imaging (MRI) revealed bone destruction and spinal cord compression within L1 and L2. mNGS testing showed that the inspected specimen collected from spinal lesion was detected positively for Coxiella burnetii. After receiving the combined treatment of antibiotic therapy and surgical intervention, the patient recovered well, and the sagittal MRI showed that vertebral edema signals disappeared and the graft of bone fused 16 months after surgery. Conclusion The mNGS may be benefit for early diagnosis and intervention of non-specific spinal infection, and future studies should validate its effectiveness for clinical use in spinal infections. Additionally, antibiotic therapy combined with surgical intervention plays an important role on the treatment of spinal infection caused by Coxiella burnetii.https://doi.org/10.1186/s12879-022-07938-7Coxiella burnetiiSpinal infectionMetagenomic next-generation sequencingCase report |
| spellingShingle | Sumin Yang Bai Xue Xiaowen Hu Weidong Zhou Minglei Zhang Mingwei Zhao Spinal infection caused by Coxiella burnetii BMC Infectious Diseases Coxiella burnetii Spinal infection Metagenomic next-generation sequencing Case report |
| title | Spinal infection caused by Coxiella burnetii |
| title_full | Spinal infection caused by Coxiella burnetii |
| title_fullStr | Spinal infection caused by Coxiella burnetii |
| title_full_unstemmed | Spinal infection caused by Coxiella burnetii |
| title_short | Spinal infection caused by Coxiella burnetii |
| title_sort | spinal infection caused by coxiella burnetii |
| topic | Coxiella burnetii Spinal infection Metagenomic next-generation sequencing Case report |
| url | https://doi.org/10.1186/s12879-022-07938-7 |
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