Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population
Abstract Background To report tumour pathology, surgical procedure, complication rates and overall outcome of periocular basal cell carcinoma (BCC) in the Department of Ophthalmology at Sygehus Lillebaelt, Southern Denmark Region over a 5-year period. Methods Medical records for all patients who und...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02494-9 |
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| author | Sveina Björk Karlsdóttir Simon Johannessen Nikolaj Carsting Bjerrum Ulrik Frydkjær-Olsen Søren Leer Blindbæk Flemming Møller Camilla Wellejus |
| author_facet | Sveina Björk Karlsdóttir Simon Johannessen Nikolaj Carsting Bjerrum Ulrik Frydkjær-Olsen Søren Leer Blindbæk Flemming Møller Camilla Wellejus |
| author_sort | Sveina Björk Karlsdóttir |
| collection | DOAJ |
| description | Abstract Background To report tumour pathology, surgical procedure, complication rates and overall outcome of periocular basal cell carcinoma (BCC) in the Department of Ophthalmology at Sygehus Lillebaelt, Southern Denmark Region over a 5-year period. Methods Medical records for all patients who underwent surgery for periocular BCC between January 2016 and December 2020 were reviewed. All tumours were excised with a 3 mm margin beyond the clinically apparent delimitation of the tumour and analysed by frozen section histological examination. Paraffin sections were subsequently examined for a final histopathological diagnosis. Patient age, gender, date of resection, former cancer history, referring unit and follow-up time were recorded. Furthermore, histological subtypes identified from biopsy and resection, lesion location, lesion diameter, free margin after the first operation, lacrimal punctum involvement, reconstructive techniques and complications were also recorded. Results A total of 242 surgical excisions from 237 patients were recorded. The mean age was 69.7 ± 12.6 with women significantly predominant compared to men (1.8:1, p < 0.0001, binomial test). The mean tumour diameter was 4.29 mm (range 0.5–20 mm). The most common location and histological subtype was the lower eyelid and nodular BCC respectively (64.9% and 74.0% of cases). In 17.4% of the patients, the initial resection margin on the frozen section histology was not free of tumour cells and the risk was significantly greater for BCC subtypes considered aggressive in terms of growth pattern (morphea form, infiltrative and micronodular features) as compared to non-aggressive BCC subtypes (nodular and superficial) (p = 0.002, X 2). In 239 (98.8%) of the patients, the BCC was found to be radically removed after final histopathological examination. The sensitivity of identification of aggressive subtypes of periocular BCC in biopsies was 47.7%. No recurrences were found during the 5-year period. Conclusion This study demonstrated a tendency towards more women than men being diagnosed with periocular BCC. The initial biopsy performed for all patients underestimated the aggressiveness of BCC in almost half of the cases while aggressive BCC subtypes were more likely to need further resection after frozen section compared to non-aggressive subtypes. |
| first_indexed | 2024-04-13T22:03:03Z |
| format | Article |
| id | doaj.art-7bb75a9297194229a81da671d6ebaefa |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T22:03:03Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-7bb75a9297194229a81da671d6ebaefa2022-12-22T02:28:01ZengBMCBMC Ophthalmology1471-24152022-06-012211610.1186/s12886-022-02494-9Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish populationSveina Björk Karlsdóttir0Simon Johannessen1Nikolaj Carsting Bjerrum2Ulrik Frydkjær-Olsen3Søren Leer Blindbæk4Flemming Møller5Camilla Wellejus6Department of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltDepartment of Ophthalmology, Sygehus LillebaeltAbstract Background To report tumour pathology, surgical procedure, complication rates and overall outcome of periocular basal cell carcinoma (BCC) in the Department of Ophthalmology at Sygehus Lillebaelt, Southern Denmark Region over a 5-year period. Methods Medical records for all patients who underwent surgery for periocular BCC between January 2016 and December 2020 were reviewed. All tumours were excised with a 3 mm margin beyond the clinically apparent delimitation of the tumour and analysed by frozen section histological examination. Paraffin sections were subsequently examined for a final histopathological diagnosis. Patient age, gender, date of resection, former cancer history, referring unit and follow-up time were recorded. Furthermore, histological subtypes identified from biopsy and resection, lesion location, lesion diameter, free margin after the first operation, lacrimal punctum involvement, reconstructive techniques and complications were also recorded. Results A total of 242 surgical excisions from 237 patients were recorded. The mean age was 69.7 ± 12.6 with women significantly predominant compared to men (1.8:1, p < 0.0001, binomial test). The mean tumour diameter was 4.29 mm (range 0.5–20 mm). The most common location and histological subtype was the lower eyelid and nodular BCC respectively (64.9% and 74.0% of cases). In 17.4% of the patients, the initial resection margin on the frozen section histology was not free of tumour cells and the risk was significantly greater for BCC subtypes considered aggressive in terms of growth pattern (morphea form, infiltrative and micronodular features) as compared to non-aggressive BCC subtypes (nodular and superficial) (p = 0.002, X 2). In 239 (98.8%) of the patients, the BCC was found to be radically removed after final histopathological examination. The sensitivity of identification of aggressive subtypes of periocular BCC in biopsies was 47.7%. No recurrences were found during the 5-year period. Conclusion This study demonstrated a tendency towards more women than men being diagnosed with periocular BCC. The initial biopsy performed for all patients underestimated the aggressiveness of BCC in almost half of the cases while aggressive BCC subtypes were more likely to need further resection after frozen section compared to non-aggressive subtypes.https://doi.org/10.1186/s12886-022-02494-9SurgeryBasal Cell CarcinomaBiopsyPathologyHistologyEyelids |
| spellingShingle | Sveina Björk Karlsdóttir Simon Johannessen Nikolaj Carsting Bjerrum Ulrik Frydkjær-Olsen Søren Leer Blindbæk Flemming Møller Camilla Wellejus Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population BMC Ophthalmology Surgery Basal Cell Carcinoma Biopsy Pathology Histology Eyelids |
| title | Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population |
| title_full | Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population |
| title_fullStr | Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population |
| title_full_unstemmed | Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population |
| title_short | Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population |
| title_sort | periocular basal cell carcinoma results and surgical outcome during a 5 year period in a larger danish population |
| topic | Surgery Basal Cell Carcinoma Biopsy Pathology Histology Eyelids |
| url | https://doi.org/10.1186/s12886-022-02494-9 |
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