miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN
Ovarian cancer (OC) is the one of the most common cancer in women globally. However, it still represents the most dangerous gynecologic malignancy even with the advances in detection and therapeutics. Thus, there is an urgent need in finding more effective therapeutic options for OC patients includi...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-02-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | https://www.ejh.it/index.php/ejh/article/view/3186 |
| _version_ | 1798023997978312704 |
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| author | Zubiao Gao Xiaofeng Ye Anne Bordeaux Stanka Hettich Siyao Lin Fang Han Yan Jia |
| author_facet | Zubiao Gao Xiaofeng Ye Anne Bordeaux Stanka Hettich Siyao Lin Fang Han Yan Jia |
| author_sort | Zubiao Gao |
| collection | DOAJ |
| description | Ovarian cancer (OC) is the one of the most common cancer in women globally. However, it still represents the most dangerous gynecologic malignancy even with the advances in detection and therapeutics. Thus, there is an urgent need in finding more effective therapeutic options for OC patients including cancer stem cells (CSC). MicroRNAs (miRNAs) are small, endogenous, and non-coding RNAs that play critical roles in the progression of various types of tumor. Our aim of this study was to find the regulatory function of microRNA-26 (miRNA-26b) on the cell proliferation and apoptosis of ovarian CSCs. Our studies show that miR-26b is under-regulated in human CD117+CD44+ ovarian CSCs. The miR-26b overexpression inhibits the cell proliferation and promotes cell apoptosis. Moreover, phosphatase and tensin homolog (PTEN) is found to be a functional target of miR-26b. Moreover, PTEN overexpression reversed the effects of miR-26b on the cell proliferation and apoptosis. PTEN overexpression remarkably accelerated the cell proliferation, and inhibited cell apoptosis. These results indicate that miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian CSCs by targeting PTEN.> |
| first_indexed | 2024-04-11T17:55:35Z |
| format | Article |
| id | doaj.art-7bb79f61c73d40e7b1beb1c4c0c59fea |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-04-11T17:55:35Z |
| publishDate | 2021-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-7bb79f61c73d40e7b1beb1c4c0c59fea2022-12-22T04:10:48ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062021-02-0165110.4081/ejh.2021.3186miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTENZubiao Gao0Xiaofeng Ye1Anne Bordeaux2Stanka Hettich3Siyao Lin4Fang Han5Yan Jia6Department of Obstetrics and Gynecology, Foshan Chancheng Central Hospital, Foshan, GuangdongDepartment of Obstetrics and Gynecology, Foshan Chancheng Central Hospital, Foshan, GuangdongDepartment of Pathology, Medical Center, University of Freiburg, Baden-WuerttembergDepartment of Obstetrics and Gynecology, Medical Center, University of Freiburg, Baden-WuerttembergDepartment of Obstetrics and Gynecology, Foshan Chancheng Central Hospital, Foshan, GuangdongDepartment of Obstetrics and Gynecology, Foshan Chancheng Central Hospital, Foshan, GuangdongDepartment of Reproductive Immunology, Chengdu Xi’ nan Gynecology Hospital, Chengdu, SichuanOvarian cancer (OC) is the one of the most common cancer in women globally. However, it still represents the most dangerous gynecologic malignancy even with the advances in detection and therapeutics. Thus, there is an urgent need in finding more effective therapeutic options for OC patients including cancer stem cells (CSC). MicroRNAs (miRNAs) are small, endogenous, and non-coding RNAs that play critical roles in the progression of various types of tumor. Our aim of this study was to find the regulatory function of microRNA-26 (miRNA-26b) on the cell proliferation and apoptosis of ovarian CSCs. Our studies show that miR-26b is under-regulated in human CD117+CD44+ ovarian CSCs. The miR-26b overexpression inhibits the cell proliferation and promotes cell apoptosis. Moreover, phosphatase and tensin homolog (PTEN) is found to be a functional target of miR-26b. Moreover, PTEN overexpression reversed the effects of miR-26b on the cell proliferation and apoptosis. PTEN overexpression remarkably accelerated the cell proliferation, and inhibited cell apoptosis. These results indicate that miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian CSCs by targeting PTEN.>https://www.ejh.it/index.php/ejh/article/view/3186miR-26bPTENovarian cancer stem cells (CSCs)cell proliferationapoptosis |
| spellingShingle | Zubiao Gao Xiaofeng Ye Anne Bordeaux Stanka Hettich Siyao Lin Fang Han Yan Jia miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN European Journal of Histochemistry miR-26b PTEN ovarian cancer stem cells (CSCs) cell proliferation apoptosis |
| title | miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN |
| title_full | miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN |
| title_fullStr | miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN |
| title_full_unstemmed | miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN |
| title_short | miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN |
| title_sort | mir 26b regulates cell proliferation and apoptosis of cd117 cd44 ovarian cancer stem cells by targeting pten |
| topic | miR-26b PTEN ovarian cancer stem cells (CSCs) cell proliferation apoptosis |
| url | https://www.ejh.it/index.php/ejh/article/view/3186 |
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