Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism
Diesel exhaust particulate matter (DEPM) are important components of urban air pollution worldwide. Recent studies proved that airborne DEPM can enter the human brain, which was associated with brain and mental diseases. In this study, we investigated the effects of DEPM exposure on behavior, and ex...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023006323 |
| _version_ | 1797349508461363200 |
|---|---|
| author | Hou Liu Guicheng Wang Jin Zhang Bingjie Lu Dan Li Jianmin Chen |
| author_facet | Hou Liu Guicheng Wang Jin Zhang Bingjie Lu Dan Li Jianmin Chen |
| author_sort | Hou Liu |
| collection | DOAJ |
| description | Diesel exhaust particulate matter (DEPM) are important components of urban air pollution worldwide. Recent studies proved that airborne DEPM can enter the human brain, which was associated with brain and mental diseases. In this study, we investigated the effects of DEPM exposure on behavior, and explored potential mechanisms from the perspective of metabolism in specific brain regions and short chain fatty acids (SCFAs) in the gut using mice. The results showed that inhalation of DEPM induced locomotor hyperactivity and a tendency for memory decline in mice. Exposure to DEPM disrupted motor behavior generation related cerebellar Purkinje cells, induced widespread reduction of neurotransmitters in the frontal cortex, and downregulated expression of genes encoding Brain-derived neurotrophic factor (BDNF) and involved in the Brain-blood-barrier (BBB) in the hippocampus. Moreover, there was a DEPM dose-dependent increase in fecal SCFA levels. Correlation analysis showed that DEPM-induced locomotor hyperactivity was mainly associated with decreased neurotransmission in the frontal cortex and increased gut SCFAs, and those associations were discussed. This study provides new insights into the mechanisms underpinning behavioral changes caused by air pollution, and extends our knowledge on the toxicity and health effects of airborne pollutants. |
| first_indexed | 2024-03-08T12:31:21Z |
| format | Article |
| id | doaj.art-7bb807a26b904c80bacd361a1222116c |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-08T12:31:21Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-7bb807a26b904c80bacd361a1222116c2024-01-22T04:14:50ZengElsevierEnvironment International0160-41202024-01-01183108359Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolismHou Liu0Guicheng Wang1Jin Zhang2Bingjie Lu3Dan Li4Jianmin Chen5Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, ChinaInstitute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai, 200433, ChinaShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, ChinaShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, ChinaShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China; Corresponding author.Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, ChinaDiesel exhaust particulate matter (DEPM) are important components of urban air pollution worldwide. Recent studies proved that airborne DEPM can enter the human brain, which was associated with brain and mental diseases. In this study, we investigated the effects of DEPM exposure on behavior, and explored potential mechanisms from the perspective of metabolism in specific brain regions and short chain fatty acids (SCFAs) in the gut using mice. The results showed that inhalation of DEPM induced locomotor hyperactivity and a tendency for memory decline in mice. Exposure to DEPM disrupted motor behavior generation related cerebellar Purkinje cells, induced widespread reduction of neurotransmitters in the frontal cortex, and downregulated expression of genes encoding Brain-derived neurotrophic factor (BDNF) and involved in the Brain-blood-barrier (BBB) in the hippocampus. Moreover, there was a DEPM dose-dependent increase in fecal SCFA levels. Correlation analysis showed that DEPM-induced locomotor hyperactivity was mainly associated with decreased neurotransmission in the frontal cortex and increased gut SCFAs, and those associations were discussed. This study provides new insights into the mechanisms underpinning behavioral changes caused by air pollution, and extends our knowledge on the toxicity and health effects of airborne pollutants.http://www.sciencedirect.com/science/article/pii/S0160412023006323Diesel exhaust particulate matter (DEPM)Behavior changesNeurotransmittersShort chain fatty acids (SCFAs) |
| spellingShingle | Hou Liu Guicheng Wang Jin Zhang Bingjie Lu Dan Li Jianmin Chen Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism Environment International Diesel exhaust particulate matter (DEPM) Behavior changes Neurotransmitters Short chain fatty acids (SCFAs) |
| title | Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| title_full | Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| title_fullStr | Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| title_full_unstemmed | Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| title_short | Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| title_sort | inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism |
| topic | Diesel exhaust particulate matter (DEPM) Behavior changes Neurotransmitters Short chain fatty acids (SCFAs) |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023006323 |
| work_keys_str_mv | AT houliu inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism AT guichengwang inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism AT jinzhang inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism AT bingjielu inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism AT danli inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism AT jianminchen inhalationofdieselexhaustparticulatematterinduceslocomotorhyperactivityanditsrelationshipwithbrainandgutmetabolism |