Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease
Abstract Neuroimaging is advancing a new definition of Alzheimer's disease (AD). Using imaging biomarkers, clinicians may begin to diagnose the disease by identifying pathology and neurodegeneration in either cognitively impaired or unimpaired adults. This “biomarker‐based” diagnosis may allow...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2018.02.006 |
| _version_ | 1818320557891911680 |
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| author | Shana D. Stites Richard Milne Jason Karlawish |
| author_facet | Shana D. Stites Richard Milne Jason Karlawish |
| author_sort | Shana D. Stites |
| collection | DOAJ |
| description | Abstract Neuroimaging is advancing a new definition of Alzheimer's disease (AD). Using imaging biomarkers, clinicians may begin to diagnose the disease by identifying pathology and neurodegeneration in either cognitively impaired or unimpaired adults. This “biomarker‐based” diagnosis may allow clinicians novel opportunities to use interventions that either delay the onset or slow the progression of cognitive decline, but it will also bring novel challenges. How will changing the definition of AD from a clinical to a biomarker construct change the experience of living with the disease? Knowledge of AD biomarker status can affect how individuals feel about themselves (internalized stigma) and how others judge them (public stigma). Following a review of AD stigma, we appraise how advances in diagnosis may enable or interrupt its transfer from clinical to preclinical stages and then explore conceptual and pragmatic challenges to addressing stigma in routine care. |
| first_indexed | 2024-12-13T10:26:55Z |
| format | Article |
| id | doaj.art-7bb8394b76c54f05ad7ae29498350c8a |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-13T10:26:55Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-7bb8394b76c54f05ad7ae29498350c8a2022-12-21T23:50:59ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110128530010.1016/j.dadm.2018.02.006Advances in Alzheimer's imaging are changing the experience of Alzheimer's diseaseShana D. Stites0Richard Milne1Jason Karlawish2Department of Medical Ethics and Health PolicyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSADepartment of Public Health and Primary CareInstitute of Public Health, University of Cambridge School of Clinical MedicineCambridgeUKDepartment of Medical Ethics and Health PolicyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSAAbstract Neuroimaging is advancing a new definition of Alzheimer's disease (AD). Using imaging biomarkers, clinicians may begin to diagnose the disease by identifying pathology and neurodegeneration in either cognitively impaired or unimpaired adults. This “biomarker‐based” diagnosis may allow clinicians novel opportunities to use interventions that either delay the onset or slow the progression of cognitive decline, but it will also bring novel challenges. How will changing the definition of AD from a clinical to a biomarker construct change the experience of living with the disease? Knowledge of AD biomarker status can affect how individuals feel about themselves (internalized stigma) and how others judge them (public stigma). Following a review of AD stigma, we appraise how advances in diagnosis may enable or interrupt its transfer from clinical to preclinical stages and then explore conceptual and pragmatic challenges to addressing stigma in routine care.https://doi.org/10.1016/j.dadm.2018.02.006StigmaAlzheimer's diseaseEarly diagnosis |
| spellingShingle | Shana D. Stites Richard Milne Jason Karlawish Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Stigma Alzheimer's disease Early diagnosis |
| title | Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease |
| title_full | Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease |
| title_fullStr | Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease |
| title_full_unstemmed | Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease |
| title_short | Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease |
| title_sort | advances in alzheimer s imaging are changing the experience of alzheimer s disease |
| topic | Stigma Alzheimer's disease Early diagnosis |
| url | https://doi.org/10.1016/j.dadm.2018.02.006 |
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