Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06756-3 |
| _version_ | 1830452861214916608 |
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| author | Chunjie Sheng Chen Yao Ziyang Wang Hongyuan Chen Yu Zhao Dazhi Xu Haojie Huang Wenlin Huang Shuai Chen |
| author_facet | Chunjie Sheng Chen Yao Ziyang Wang Hongyuan Chen Yu Zhao Dazhi Xu Haojie Huang Wenlin Huang Shuai Chen |
| author_sort | Chunjie Sheng |
| collection | DOAJ |
| description | Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli. |
| first_indexed | 2024-12-21T08:56:51Z |
| format | Article |
| id | doaj.art-7bb886e5b2aa4f5c8ea397430fc385f0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:56:51Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7bb886e5b2aa4f5c8ea397430fc385f02022-12-21T19:09:32ZengNature PortfolioNature Communications2041-17232018-10-019111310.1038/s41467-018-06756-3Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensingChunjie Sheng0Chen Yao1Ziyang Wang2Hongyuan Chen3Yu Zhao4Dazhi Xu5Haojie Huang6Wenlin Huang7Shuai Chen8Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineDepartment of Pathogen Biology and Immunology, School of Basic Course, Guangdong Pharmaceutical UniversityDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer MedicineNuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli.https://doi.org/10.1038/s41467-018-06756-3 |
| spellingShingle | Chunjie Sheng Chen Yao Ziyang Wang Hongyuan Chen Yu Zhao Dazhi Xu Haojie Huang Wenlin Huang Shuai Chen Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing Nature Communications |
| title | Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing |
| title_full | Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing |
| title_fullStr | Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing |
| title_full_unstemmed | Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing |
| title_short | Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing |
| title_sort | cyclophilin j limits inflammation through the blockage of ubiquitin chain sensing |
| url | https://doi.org/10.1038/s41467-018-06756-3 |
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