Benefits of multistrain bacteria formulations for health
Gut microbiota dysfunction is associated with multiple gastrointestinal and extra-gastrointestinal diseases, thus the possibility of its modulation with prebiotics, probiotics and symbiotics has gained interest in the last years. Many probiotics are available on the market and products characterized...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618302688 |
| _version_ | 1818563137575583744 |
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| author | L. Laterza G. Gibiino F. Scaldaferri A. Gasbarrini |
| author_facet | L. Laterza G. Gibiino F. Scaldaferri A. Gasbarrini |
| author_sort | L. Laterza |
| collection | DOAJ |
| description | Gut microbiota dysfunction is associated with multiple gastrointestinal and extra-gastrointestinal diseases, thus the possibility of its modulation with prebiotics, probiotics and symbiotics has gained interest in the last years. Many probiotics are available on the market and products characterized by combination of multiple strains have been proposed as particularly effective. However, evidences supporting their efficacy are often inadequate and not homogenous. We reviewed available data on clinical efficacy of multistrain probiotics and symbiotics in gastrointestinal diseases in adults, focusing on data from randomised, double-blind, placebo-controlled clinical trials. Twenty-nine multistrain products satisfied inclusion criteria. The principal areas of application are irritable bowel syndrome, Helicobacter pylori eradication and antibiotic-associated diarrhoea. The most represented probiotic species in the different probiotic formulations was L. acidophilus. The combination of L. paracasei, L. plantarum, L. acidophilus, L. delbrueckii subsp. bulgaricus, B. longum, B. infantis, B. breve and S. thermophilus (VSL#3) showed the highest number of RCTs. |
| first_indexed | 2024-12-14T01:12:53Z |
| format | Article |
| id | doaj.art-7bb98e3cbc48403eb3ba5d00bf88ea4c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:12:53Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-7bb98e3cbc48403eb3ba5d00bf88ea4c2022-12-21T23:22:40ZengElsevierJournal of Functional Foods1756-46462018-08-0147531546Benefits of multistrain bacteria formulations for healthL. Laterza0G. Gibiino1F. Scaldaferri2A. Gasbarrini3Corresponding author at: Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, L. go A. Gemelli, 800168 Rome, Italy.; Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, ItalyInternal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, ItalyInternal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, ItalyInternal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, ItalyGut microbiota dysfunction is associated with multiple gastrointestinal and extra-gastrointestinal diseases, thus the possibility of its modulation with prebiotics, probiotics and symbiotics has gained interest in the last years. Many probiotics are available on the market and products characterized by combination of multiple strains have been proposed as particularly effective. However, evidences supporting their efficacy are often inadequate and not homogenous. We reviewed available data on clinical efficacy of multistrain probiotics and symbiotics in gastrointestinal diseases in adults, focusing on data from randomised, double-blind, placebo-controlled clinical trials. Twenty-nine multistrain products satisfied inclusion criteria. The principal areas of application are irritable bowel syndrome, Helicobacter pylori eradication and antibiotic-associated diarrhoea. The most represented probiotic species in the different probiotic formulations was L. acidophilus. The combination of L. paracasei, L. plantarum, L. acidophilus, L. delbrueckii subsp. bulgaricus, B. longum, B. infantis, B. breve and S. thermophilus (VSL#3) showed the highest number of RCTs.http://www.sciencedirect.com/science/article/pii/S1756464618302688Multistrain probioticsGastrointestinal diseaseGut microbiotaVSL#3Irritable bowel syndromeH. pylori |
| spellingShingle | L. Laterza G. Gibiino F. Scaldaferri A. Gasbarrini Benefits of multistrain bacteria formulations for health Journal of Functional Foods Multistrain probiotics Gastrointestinal disease Gut microbiota VSL#3 Irritable bowel syndrome H. pylori |
| title | Benefits of multistrain bacteria formulations for health |
| title_full | Benefits of multistrain bacteria formulations for health |
| title_fullStr | Benefits of multistrain bacteria formulations for health |
| title_full_unstemmed | Benefits of multistrain bacteria formulations for health |
| title_short | Benefits of multistrain bacteria formulations for health |
| title_sort | benefits of multistrain bacteria formulations for health |
| topic | Multistrain probiotics Gastrointestinal disease Gut microbiota VSL#3 Irritable bowel syndrome H. pylori |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618302688 |
| work_keys_str_mv | AT llaterza benefitsofmultistrainbacteriaformulationsforhealth AT ggibiino benefitsofmultistrainbacteriaformulationsforhealth AT fscaldaferri benefitsofmultistrainbacteriaformulationsforhealth AT agasbarrini benefitsofmultistrainbacteriaformulationsforhealth |