Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II
In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regula...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2015-11-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/64 |
| _version_ | 1828874451679182848 |
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| author | Andrea Salzano Domenico Sirico Michele Arcopinto Alberto Maria Marra Germano Guerra Aldo Rocca Alessandra Grieco Francesco Giallauria Carlo Vigorito |
| author_facet | Andrea Salzano Domenico Sirico Michele Arcopinto Alberto Maria Marra Germano Guerra Aldo Rocca Alessandra Grieco Francesco Giallauria Carlo Vigorito |
| author_sort | Andrea Salzano |
| collection | DOAJ |
| description | In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. After the evaluation of the results obtained from gene therapy and stem cells, in this part we evaluate micro- RNA, post-translational modification and microspheres based therapy. |
| first_indexed | 2024-12-13T07:37:24Z |
| format | Article |
| id | doaj.art-7bba699c23a84128bdbf091ce89d8847 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-13T07:37:24Z |
| publishDate | 2015-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-7bba699c23a84128bdbf091ce89d88472022-12-21T23:55:02ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642015-11-0182410.4081/monaldi.2014.64Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part IIAndrea Salzano0Domenico Sirico1Michele Arcopinto2Alberto Maria Marra3Germano Guerra4Aldo Rocca5Alessandra Grieco6Francesco Giallauria7Carlo Vigorito8Department of Traslational Medical Sciences, University Federico II, NaplesDepartment of Traslational Medical Sciences, University Federico II, NaplesDepartment of Cardiac Surgery, IRCCS Policlinico San Donato, MilanDepartment of Traslational Medical Sciences, University Federico II, NaplesDepartment of Medicine and Health Sciences, University of Molise, CampobassoDepartment of Clinical Medicine and Surgery, University of Naples “Federico II”, NaplesDepartment of Traslational Medical Sciences, University Federico II, NaplesDepartment of Traslational Medical Sciences, University Federico II, NaplesDepartment of Traslational Medical Sciences, University Federico II, NaplesIn recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. After the evaluation of the results obtained from gene therapy and stem cells, in this part we evaluate micro- RNA, post-translational modification and microspheres based therapy.https://www.monaldi-archives.org/index.php/macd/article/view/64cardiac remodelinggene therapystem cellsmicro-RNAmicrospheresheart failure. |
| spellingShingle | Andrea Salzano Domenico Sirico Michele Arcopinto Alberto Maria Marra Germano Guerra Aldo Rocca Alessandra Grieco Francesco Giallauria Carlo Vigorito Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II Monaldi Archives for Chest Disease cardiac remodeling gene therapy stem cells micro-RNA microspheres heart failure. |
| title | Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II |
| title_full | Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II |
| title_fullStr | Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II |
| title_full_unstemmed | Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II |
| title_short | Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure. Part II |
| title_sort | anti remodeling therapy new strategies and future perspective in post ischemic heart failure part ii |
| topic | cardiac remodeling gene therapy stem cells micro-RNA microspheres heart failure. |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/64 |
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