Regulation of NcRNA-protein binding in diabetic foot
Non-coding RNA (ncRNA) is a special type of RNA transcript that makes up more than 90 % of the human genome. Although ncRNA typically does not encode proteins, it indirectly controls a wide range of biological processes, including cellular metabolism, development, proliferation, transcription, and p...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222300149X |
| _version_ | 1797894741885452288 |
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| author | Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu |
| author_facet | Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu |
| author_sort | Yujia Zhang |
| collection | DOAJ |
| description | Non-coding RNA (ncRNA) is a special type of RNA transcript that makes up more than 90 % of the human genome. Although ncRNA typically does not encode proteins, it indirectly controls a wide range of biological processes, including cellular metabolism, development, proliferation, transcription, and post-transcriptional modification. NcRNAs include small interfering RNA (siRNA), PIWI-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA), etc. The most researched of these are miRNA, lncRNA, and circRNA, which are crucial regulators in the onset of diabetes and the development of associated consequences. The ncRNAs indicated above are linked to numerous diabetes problems by binding proteins, including diabetic foot (DF), diabetic nephropathy, diabetic cardiomyopathy, and diabetic peripheral neuropathy. According to recent studies, Mir-146a can control the AKAP12 axis to promote the proliferation and migration of diabetic foot ulcer (DFU) cells, while lncRNA GAS5 can activate HIF1A/VEGF pathway by binding to TAF15 to promote DFU wound healing. However, there are still many unanswered questions about the mechanism of action of ncRNAs. In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU. |
| first_indexed | 2024-04-10T07:14:08Z |
| format | Article |
| id | doaj.art-7bbbbe7a7aa74da9934cf48c08559428 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T07:14:08Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7bbbbe7a7aa74da9934cf48c085594282023-02-26T04:26:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-04-01160114361Regulation of NcRNA-protein binding in diabetic footYujia Zhang0Jing Zhang1Zhou Xu2Deju Zhang3Panpan Xia4Jitao Ling5Xiaoyi Tang6Xiao Liu7Rui Xuan8Meiying Zhang9Jianping Liu10Peng Yu11Huankui College, Nanchang University, Nanchang, Jiangxi, China; Department of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaFood and Nutritional Sciences, School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaDepartment of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China; Correspondence to: Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, 1st Minde Road, Nanchang, Jiangxi Province, China.Department of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China; Correspondence to: Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, 1st Minde Road, Nanchang, Jiangxi Province, China.Non-coding RNA (ncRNA) is a special type of RNA transcript that makes up more than 90 % of the human genome. Although ncRNA typically does not encode proteins, it indirectly controls a wide range of biological processes, including cellular metabolism, development, proliferation, transcription, and post-transcriptional modification. NcRNAs include small interfering RNA (siRNA), PIWI-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA), etc. The most researched of these are miRNA, lncRNA, and circRNA, which are crucial regulators in the onset of diabetes and the development of associated consequences. The ncRNAs indicated above are linked to numerous diabetes problems by binding proteins, including diabetic foot (DF), diabetic nephropathy, diabetic cardiomyopathy, and diabetic peripheral neuropathy. According to recent studies, Mir-146a can control the AKAP12 axis to promote the proliferation and migration of diabetic foot ulcer (DFU) cells, while lncRNA GAS5 can activate HIF1A/VEGF pathway by binding to TAF15 to promote DFU wound healing. However, there are still many unanswered questions about the mechanism of action of ncRNAs. In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU.http://www.sciencedirect.com/science/article/pii/S075333222300149Xnon-coding RNAdiabetic footdiabetic foot ulcermicro RNA |
| spellingShingle | Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu Regulation of NcRNA-protein binding in diabetic foot Biomedicine & Pharmacotherapy non-coding RNA diabetic foot diabetic foot ulcer micro RNA |
| title | Regulation of NcRNA-protein binding in diabetic foot |
| title_full | Regulation of NcRNA-protein binding in diabetic foot |
| title_fullStr | Regulation of NcRNA-protein binding in diabetic foot |
| title_full_unstemmed | Regulation of NcRNA-protein binding in diabetic foot |
| title_short | Regulation of NcRNA-protein binding in diabetic foot |
| title_sort | regulation of ncrna protein binding in diabetic foot |
| topic | non-coding RNA diabetic foot diabetic foot ulcer micro RNA |
| url | http://www.sciencedirect.com/science/article/pii/S075333222300149X |
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