Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD
The GGGGCC repeat expansion in C9ORF72-ALS/FTD can be translated into five dipeptide repeat (DPR) proteins, including poly(GR) and poly(GA). Here, the authors develop assays to detect the levels of these DPR proteins in the CSF of individuals with ALS/FTD.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30387-4 |
| _version_ | 1818240876382519296 |
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| author | Gopinath Krishnan Denitza Raitcheva Daniel Bartlett Mercedes Prudencio Diane M. McKenna-Yasek Catherine Douthwright Björn E. Oskarsson Shafeeq Ladha Oliver D. King Sami J. Barmada Timothy M. Miller Robert Bowser Jonathan K. Watts Leonard Petrucelli Robert H. Brown Mark W. Kankel Fen-Biao Gao |
| author_facet | Gopinath Krishnan Denitza Raitcheva Daniel Bartlett Mercedes Prudencio Diane M. McKenna-Yasek Catherine Douthwright Björn E. Oskarsson Shafeeq Ladha Oliver D. King Sami J. Barmada Timothy M. Miller Robert Bowser Jonathan K. Watts Leonard Petrucelli Robert H. Brown Mark W. Kankel Fen-Biao Gao |
| author_sort | Gopinath Krishnan |
| collection | DOAJ |
| description | The GGGGCC repeat expansion in C9ORF72-ALS/FTD can be translated into five dipeptide repeat (DPR) proteins, including poly(GR) and poly(GA). Here, the authors develop assays to detect the levels of these DPR proteins in the CSF of individuals with ALS/FTD. |
| first_indexed | 2024-12-12T13:20:24Z |
| format | Article |
| id | doaj.art-7bbca0a96b9d4736acc9cdb625fcce18 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T13:20:24Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7bbca0a96b9d4736acc9cdb625fcce182022-12-22T00:23:19ZengNature PortfolioNature Communications2041-17232022-05-011311810.1038/s41467-022-30387-4Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTDGopinath Krishnan0Denitza Raitcheva1Daniel Bartlett2Mercedes Prudencio3Diane M. McKenna-Yasek4Catherine Douthwright5Björn E. Oskarsson6Shafeeq Ladha7Oliver D. King8Sami J. Barmada9Timothy M. Miller10Robert Bowser11Jonathan K. Watts12Leonard Petrucelli13Robert H. Brown14Mark W. Kankel15Fen-Biao Gao16Department of Neurology, University of Massachusetts Chan Medical SchoolBiomarkers, Clinical Sciences BiogenBiomarkers, Clinical Sciences BiogenDepartment of Neuroscience, Mayo ClinicDepartment of Neurology, University of Massachusetts Chan Medical SchoolDepartment of Neurology, University of Massachusetts Chan Medical SchoolDepartment of Neurology, Mayo ClinicDepartments of Neurology and Translational Neuroscience, St. Joseph’s Hospital and Medical Center and Barrow Neurological InstituteDepartment of Neurology, University of Massachusetts Chan Medical SchoolDepartment of Neurology, University of Michigan, 4005 BSRBDepartment of Neurology, Washington UniversityDepartments of Neurology and Translational Neuroscience, St. Joseph’s Hospital and Medical Center and Barrow Neurological InstituteRNA Therapeutics Institute and Department of Biochemistry and Molecular Pharmacology, UMass Chan Medical SchoolDepartment of Neuroscience, Mayo ClinicDepartment of Neurology, University of Massachusetts Chan Medical SchoolNeuromuscular & Movement Disorders, BiogenDepartment of Neurology, University of Massachusetts Chan Medical SchoolThe GGGGCC repeat expansion in C9ORF72-ALS/FTD can be translated into five dipeptide repeat (DPR) proteins, including poly(GR) and poly(GA). Here, the authors develop assays to detect the levels of these DPR proteins in the CSF of individuals with ALS/FTD.https://doi.org/10.1038/s41467-022-30387-4 |
| spellingShingle | Gopinath Krishnan Denitza Raitcheva Daniel Bartlett Mercedes Prudencio Diane M. McKenna-Yasek Catherine Douthwright Björn E. Oskarsson Shafeeq Ladha Oliver D. King Sami J. Barmada Timothy M. Miller Robert Bowser Jonathan K. Watts Leonard Petrucelli Robert H. Brown Mark W. Kankel Fen-Biao Gao Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD Nature Communications |
| title | Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD |
| title_full | Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD |
| title_fullStr | Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD |
| title_full_unstemmed | Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD |
| title_short | Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD |
| title_sort | poly gr and poly ga in cerebrospinal fluid as potential biomarkers for c9orf72 als ftd |
| url | https://doi.org/10.1038/s41467-022-30387-4 |
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