Interlukin-4 weakens resistance to stress injury and megakaryocytic differentiation of hematopoietic stem cells by inhibiting Psmd13 expression
Abstract Thrombocytopenia is a major and fatal complication in patients with acute myeloid leukemia (AML), which results from disrupted megakaryopoiesis by leukemic niche and blasts. Our previous research revealed that elevated interleukin-4 (IL-4) in AML bone marrow had adverse impact on multiple s...
Main Authors: | Ai Gao, Shuhui Xu, Qing Li, Caiying Zhu, Fengjiao Wang, Yajie Wang, Sha Hao, Fang Dong, Hui Cheng, Tao Cheng, Yuemin Gong |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-41479-6 |
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