Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle
Reproductive efficiency plays a major role in the long-term sustainability of livestock industries and can be improved through genetic and genomic selection. This study aimed to estimate genetic parameters (heritability and genetic correlation) and identify genomic regions and candidate genes associ...
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MDPI AG
2020-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/7/1185 |
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| author | Laís Grigoletto Miguel Henrique Almeida Santana Fabiana Fernandes Bressan Joanir Pereira Eler Marcelo Fábio Gouveia Nogueira Haja N. Kadarmideen Pietro Sampaio Baruselli José Bento Sterman Ferraz Luiz F. Brito |
| author_facet | Laís Grigoletto Miguel Henrique Almeida Santana Fabiana Fernandes Bressan Joanir Pereira Eler Marcelo Fábio Gouveia Nogueira Haja N. Kadarmideen Pietro Sampaio Baruselli José Bento Sterman Ferraz Luiz F. Brito |
| author_sort | Laís Grigoletto |
| collection | DOAJ |
| description | Reproductive efficiency plays a major role in the long-term sustainability of livestock industries and can be improved through genetic and genomic selection. This study aimed to estimate genetic parameters (heritability and genetic correlation) and identify genomic regions and candidate genes associated with anti-Müllerian hormone levels (AMH) and antral follicle populations measured after estrous synchronization (AFP) in Nellore cattle. The datasets included phenotypic records for 1099 and 289 Nellore females for AFP and AMH, respectively, high-density single nucleotide polymorphism (SNP) genotypes for 944 animals, and 4129 individuals in the pedigree. The heritability estimates for AMH and AFP were 0.28 ± 0.07 and 0.30 ± 0.09, and the traits were highly and positively genetically correlated (<i>r<sub>G</sub></i> = 0.81 ± 0.02). These findings indicated that these traits can be improved through selective breeding, and substantial indirect genetic gains are expected by selecting for only one of the two traits. A total of 31 genomic regions were shown to be associated with AMH or AFP, and two genomic regions located on BTA1 (64.9–65.0 Mb and 109.1–109.2 Mb) overlapped between the traits. Various candidate genes were identified to be potentially linked to important biological processes such as ovulation, tissue remodeling, and the immune system. Our findings support the use of AMH and AFP as indicator traits to genetically improve fertility rates in Nellore cattle and identify better oocyte donors. |
| first_indexed | 2024-03-09T06:10:29Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T06:10:29Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-7bc0b19d334442c092fee2c5a34b5e372023-12-03T11:58:41ZengMDPI AGAnimals2076-26152020-07-01107118510.3390/ani10071185Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore CattleLaís Grigoletto0Miguel Henrique Almeida Santana1Fabiana Fernandes Bressan2Joanir Pereira Eler3Marcelo Fábio Gouveia Nogueira4Haja N. Kadarmideen5Pietro Sampaio Baruselli6José Bento Sterman Ferraz7Luiz F. Brito8Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USADepartment of Veterinary Medicine, College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, 13635-900 São Paulo, BrazilDepartment of Veterinary Medicine, College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, 13635-900 São Paulo, BrazilDepartment of Veterinary Medicine, College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, 13635-900 São Paulo, BrazilDepartment of Biological Sciences, School of Sciences and Languages, São Paulo State University, Assis, 19806-900 São Paulo, BrazilDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, 102500 Lyngby, DenmarkCollege of Veterinary Medicine and Animal Science, University of Sao Paulo, 05508-270 São Paulo, BrazilDepartment of Veterinary Medicine, College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, 13635-900 São Paulo, BrazilDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USAReproductive efficiency plays a major role in the long-term sustainability of livestock industries and can be improved through genetic and genomic selection. This study aimed to estimate genetic parameters (heritability and genetic correlation) and identify genomic regions and candidate genes associated with anti-Müllerian hormone levels (AMH) and antral follicle populations measured after estrous synchronization (AFP) in Nellore cattle. The datasets included phenotypic records for 1099 and 289 Nellore females for AFP and AMH, respectively, high-density single nucleotide polymorphism (SNP) genotypes for 944 animals, and 4129 individuals in the pedigree. The heritability estimates for AMH and AFP were 0.28 ± 0.07 and 0.30 ± 0.09, and the traits were highly and positively genetically correlated (<i>r<sub>G</sub></i> = 0.81 ± 0.02). These findings indicated that these traits can be improved through selective breeding, and substantial indirect genetic gains are expected by selecting for only one of the two traits. A total of 31 genomic regions were shown to be associated with AMH or AFP, and two genomic regions located on BTA1 (64.9–65.0 Mb and 109.1–109.2 Mb) overlapped between the traits. Various candidate genes were identified to be potentially linked to important biological processes such as ovulation, tissue remodeling, and the immune system. Our findings support the use of AMH and AFP as indicator traits to genetically improve fertility rates in Nellore cattle and identify better oocyte donors.https://www.mdpi.com/2076-2615/10/7/1185anti-Müllerianbiomarkerfertility rateindicineGWASheritability |
| spellingShingle | Laís Grigoletto Miguel Henrique Almeida Santana Fabiana Fernandes Bressan Joanir Pereira Eler Marcelo Fábio Gouveia Nogueira Haja N. Kadarmideen Pietro Sampaio Baruselli José Bento Sterman Ferraz Luiz F. Brito Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle Animals anti-Müllerian biomarker fertility rate indicine GWAS heritability |
| title | Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle |
| title_full | Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle |
| title_fullStr | Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle |
| title_full_unstemmed | Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle |
| title_short | Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle |
| title_sort | genetic parameters and genome wide association studies for anti mullerian hormone levels and antral follicle populations measured after estrus synchronization in nellore cattle |
| topic | anti-Müllerian biomarker fertility rate indicine GWAS heritability |
| url | https://www.mdpi.com/2076-2615/10/7/1185 |
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