NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections
Risks related to tumors development against a background of viral infections as well as factors that determine such risks or reduce them have not been examined profoundly so far. Our research goal was to accomplish a scientific review of research on a potential possessed by populations of lectin NK-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
2019-03-01
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| Series: | Analiz Riska Zdorovʹû |
| Subjects: | |
| Online Access: | http://journal.fcrisk.ru/eng/2019/1/16 |
| Summary: | Risks related to tumors development against a background of viral infections as well as factors that determine such risks or reduce them have not been examined profoundly so far. Our research goal was to accomplish a scientific review of research on a potential possessed by populations of lectin NK-cells (natural killers) in a body; such populations can have variable sets of lectin and other functionally significant cell surface receptors against tumors in a situation when viruses, including epidemically significant ones, penetrate a body. It is shown that co-functioning of various receptors and their ligands that redistribute cytokines (glycopattern-identifying lectin (basis) receptors, Ig-similar receptors, cytotoxic receptors, and other effector (adjusting) receptors) plays a significant role in intercellular communications and effects produced by NK-populations. NK-populations network is a promising resource for body protection and it should be taken into account when developing new anti-tumor and anti-viral preventive and medical strategies. When certain NK-populations with protective functions are absent in a body, it can be considered a new multi-factor risk of viral and oncologic diseases in an individual or a contingent living in a specific region. The reviewed data can be applied to develop new anti-tumor and anti-viral medications and vaccines as well as medical strategies. Probiotic lectins are promising ligands of intercellular communications associated with immune surveillance. |
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| ISSN: | 2308-1155 2308-1163 |