The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer
Primary liver cancer is one of the leading causes of cancer death worldwide. Surgical and non-surgical treatments are optional for liver cancer therapy based on the cancer stage. Accumulating studies show that the gut–liver axis influences the progression of liver diseases, including liver inflammat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.524205/full |
| _version_ | 1818932694031007744 |
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| author | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson |
| author_facet | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson |
| author_sort | Chunye Zhang |
| collection | DOAJ |
| description | Primary liver cancer is one of the leading causes of cancer death worldwide. Surgical and non-surgical treatments are optional for liver cancer therapy based on the cancer stage. Accumulating studies show that the gut–liver axis influences the progression of liver diseases, including liver inflammation, fibrosis, cirrhosis, and cancer. However, the role of gut microbiota and their derived components and metabolites in liver cancer remains to be further clarified. In this review, we discuss the roles of gut microbiota and specific bacterial species in HCC and the strategies to modulate gut microbiota to improve antitumor therapy. Given the limitation of current treatments, gut microbiota-mediated therapy is a potential option for HCC treatment, including fiber diet and vegetable diet, antimicrobials, probiotics, and pharmaceutical inhibitors. Also, gut microbiota can be used as a marker for early diagnosis of HCC. HCC occurs dependent on various environmental and genetic factors, including diet and sex. Furthermore, gut microbiota impacts the immunotherapy of HCC treatment. Therefore, a better understanding of the role of the gut–liver axis in liver cancer is critically important to improve therapeutic efficacy. |
| first_indexed | 2024-12-20T04:36:33Z |
| format | Article |
| id | doaj.art-7bc22e70c39e419eb0faf01c2e7f8372 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T04:36:33Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7bc22e70c39e419eb0faf01c2e7f83722022-12-21T19:53:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.524205524205The Potential Gut Microbiota-Mediated Treatment Options for Liver CancerChunye Zhang0Ming Yang1Aaron C. Ericsson2Aaron C. Ericsson3Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United StatesDepartment of Surgery, University of Missouri, Columbia, MO, United StatesDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO, United StatesUniversity of Missouri Metagenomics Center, University of Missouri, Columbia, MO, United StatesPrimary liver cancer is one of the leading causes of cancer death worldwide. Surgical and non-surgical treatments are optional for liver cancer therapy based on the cancer stage. Accumulating studies show that the gut–liver axis influences the progression of liver diseases, including liver inflammation, fibrosis, cirrhosis, and cancer. However, the role of gut microbiota and their derived components and metabolites in liver cancer remains to be further clarified. In this review, we discuss the roles of gut microbiota and specific bacterial species in HCC and the strategies to modulate gut microbiota to improve antitumor therapy. Given the limitation of current treatments, gut microbiota-mediated therapy is a potential option for HCC treatment, including fiber diet and vegetable diet, antimicrobials, probiotics, and pharmaceutical inhibitors. Also, gut microbiota can be used as a marker for early diagnosis of HCC. HCC occurs dependent on various environmental and genetic factors, including diet and sex. Furthermore, gut microbiota impacts the immunotherapy of HCC treatment. Therefore, a better understanding of the role of the gut–liver axis in liver cancer is critically important to improve therapeutic efficacy.https://www.frontiersin.org/article/10.3389/fonc.2020.524205/fullliver cancertreatmentssexgut microbiotaclinical trials |
| spellingShingle | Chunye Zhang Ming Yang Aaron C. Ericsson Aaron C. Ericsson The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer Frontiers in Oncology liver cancer treatments sex gut microbiota clinical trials |
| title | The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer |
| title_full | The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer |
| title_fullStr | The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer |
| title_full_unstemmed | The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer |
| title_short | The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer |
| title_sort | potential gut microbiota mediated treatment options for liver cancer |
| topic | liver cancer treatments sex gut microbiota clinical trials |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.524205/full |
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