The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy
<h4>Background</h4> To evaluate the prognostic impact of lymph node dissection (LND) in patients who underwent radical nephroureterectomy (RNU) with bladder cuff excision (BCE) for clinically node-negative (cN0) upper urinary tract urothelial carcinoma (UTUC). <h4>Methods</h4>...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714942/?tool=EBI |
| _version_ | 1811208999501037568 |
|---|---|
| author | Hsiang-Chen Hsieh Chun-Li Wang Chuan-Shu Chen Cheng-Kuang Yang Jian-Ri Li Shian-Shiang Wang Chen-Li Cheng Chia-Yen Lin Kun-Yuan Chiu |
| author_facet | Hsiang-Chen Hsieh Chun-Li Wang Chuan-Shu Chen Cheng-Kuang Yang Jian-Ri Li Shian-Shiang Wang Chen-Li Cheng Chia-Yen Lin Kun-Yuan Chiu |
| author_sort | Hsiang-Chen Hsieh |
| collection | DOAJ |
| description | <h4>Background</h4> To evaluate the prognostic impact of lymph node dissection (LND) in patients who underwent radical nephroureterectomy (RNU) with bladder cuff excision (BCE) for clinically node-negative (cN0) upper urinary tract urothelial carcinoma (UTUC). <h4>Methods</h4> We retrospectively enrolled 520 patients with cN0 UTUC in a single tertiary referral center from 2000 to 2015. The patients were divided into three groups: patients with and without pathologically proved lymph node metastasis (pN1–3 and pN0, respectively) and patients without LND (pNx). We analyzed associations between overall survival (OS)/ disease-free survival (DFS)/ cancer-specific survival (CSS) and clinical characteristics. <h4>Results</h4> The patients were divided into three groups (pN1–3, pN0 and pNx with 20, 303, and 197 patients, respectively). OS/DFS/CSS in the pN1–3 group were significantly worse (all p<0.001) compared with the pN0 group. However, there were no significant differences between the pNx and pN0 groups. In the multivariate analyses, CSS was only affected by age [(hazard ratio (HR) = 1.03, p = 0.008]), positive surgical margin (HR = 3.38, p<0.001) and pathological T3–4 stages (HR = 4.07, p<0.001). In the subgroup analyses for patients with LND, locally advanced disease (pT3 and pT4) had significantly more metastases [T3–4: 13.91% (16/115) vs. T0–2: 1.92% (4/208), p<0.001]. <h4>Conclusions</h4> In the pN0 group, LND for cN0 UTUC did not show therapeutic benefits in terms of DFS, CSS, and OS. However, LND with RNU allowed optimal tumor staging, through patients still had a poor prognosis. Clinically occult LN metastases were found in 6.2% of our patients. |
| first_indexed | 2024-04-12T04:31:17Z |
| format | Article |
| id | doaj.art-7bc471fa9e42454a878ba2753c4cbd0d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T04:31:17Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7bc471fa9e42454a878ba2753c4cbd0d2022-12-22T03:47:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomyHsiang-Chen HsiehChun-Li WangChuan-Shu ChenCheng-Kuang YangJian-Ri LiShian-Shiang WangChen-Li ChengChia-Yen LinKun-Yuan Chiu<h4>Background</h4> To evaluate the prognostic impact of lymph node dissection (LND) in patients who underwent radical nephroureterectomy (RNU) with bladder cuff excision (BCE) for clinically node-negative (cN0) upper urinary tract urothelial carcinoma (UTUC). <h4>Methods</h4> We retrospectively enrolled 520 patients with cN0 UTUC in a single tertiary referral center from 2000 to 2015. The patients were divided into three groups: patients with and without pathologically proved lymph node metastasis (pN1–3 and pN0, respectively) and patients without LND (pNx). We analyzed associations between overall survival (OS)/ disease-free survival (DFS)/ cancer-specific survival (CSS) and clinical characteristics. <h4>Results</h4> The patients were divided into three groups (pN1–3, pN0 and pNx with 20, 303, and 197 patients, respectively). OS/DFS/CSS in the pN1–3 group were significantly worse (all p<0.001) compared with the pN0 group. However, there were no significant differences between the pNx and pN0 groups. In the multivariate analyses, CSS was only affected by age [(hazard ratio (HR) = 1.03, p = 0.008]), positive surgical margin (HR = 3.38, p<0.001) and pathological T3–4 stages (HR = 4.07, p<0.001). In the subgroup analyses for patients with LND, locally advanced disease (pT3 and pT4) had significantly more metastases [T3–4: 13.91% (16/115) vs. T0–2: 1.92% (4/208), p<0.001]. <h4>Conclusions</h4> In the pN0 group, LND for cN0 UTUC did not show therapeutic benefits in terms of DFS, CSS, and OS. However, LND with RNU allowed optimal tumor staging, through patients still had a poor prognosis. Clinically occult LN metastases were found in 6.2% of our patients.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714942/?tool=EBI |
| spellingShingle | Hsiang-Chen Hsieh Chun-Li Wang Chuan-Shu Chen Cheng-Kuang Yang Jian-Ri Li Shian-Shiang Wang Chen-Li Cheng Chia-Yen Lin Kun-Yuan Chiu The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy PLoS ONE |
| title | The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| title_full | The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| title_fullStr | The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| title_full_unstemmed | The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| title_short | The prognostic impact of lymph node dissection for clinically node-negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| title_sort | prognostic impact of lymph node dissection for clinically node negative upper urinary tract urothelial carcinoma in patients who are treated with radical nephroureterectomy |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714942/?tool=EBI |
| work_keys_str_mv | AT hsiangchenhsieh theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chunliwang theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chuanshuchen theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chengkuangyang theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT jianrili theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT shianshiangwang theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chenlicheng theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chiayenlin theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT kunyuanchiu theprognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT hsiangchenhsieh prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chunliwang prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chuanshuchen prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chengkuangyang prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT jianrili prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT shianshiangwang prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chenlicheng prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT chiayenlin prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy AT kunyuanchiu prognosticimpactoflymphnodedissectionforclinicallynodenegativeupperurinarytracturothelialcarcinomainpatientswhoaretreatedwithradicalnephroureterectomy |