Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC
In this paper we report long-term therapy management based on iterative de novo molecular and cellular analysis in a case of metastatic non-small cell lung cancer (NSCLC), with prior history of treated colorectal cancer. In the described case temporal tumor evolution, emergent therapy resistance and...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/9/3/34 |
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| author | Anantbhushan Ranade Darshana Patil Amit Bhatt Rucha Dhasare Vineet Datta Rajan Datar Dadasaheb Akolkar |
| author_facet | Anantbhushan Ranade Darshana Patil Amit Bhatt Rucha Dhasare Vineet Datta Rajan Datar Dadasaheb Akolkar |
| author_sort | Anantbhushan Ranade |
| collection | DOAJ |
| description | In this paper we report long-term therapy management based on iterative de novo molecular and cellular analysis in a case of metastatic non-small cell lung cancer (NSCLC), with prior history of treated colorectal cancer. In the described case temporal tumor evolution, emergent therapy resistance and disease recurrences were addressed via the administration of personalized label- and organ-agnostic treatments based on de novo tumor profiling. This adaptive and iterative treatment strategy countered disease progression at each instance and led to the durable regression of primary as well as metastatic lesions. Concurrently, serial evaluation of mutations in cell-free circulating tumor DNA (ctDNA) via liquid biopsy (LBx) was performed to monitor disease status, ascertain treatment response, identify emergent drug resistance and detect recurrence at sub-radiological levels. The treatment management strategy described herein effectively addressed multiple, sequential clinical conundrums for which viable options were unavailable under the current Standard of Care (SoC). |
| first_indexed | 2024-04-10T18:11:33Z |
| format | Article |
| id | doaj.art-7bc4a40f15dc48c2962c7653ed1c9c78 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-04-10T18:11:33Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-7bc4a40f15dc48c2962c7653ed1c9c782023-02-02T10:43:45ZengMDPI AGJournal of Personalized Medicine2075-44262019-07-01933410.3390/jpm9030034jpm9030034Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLCAnantbhushan Ranade0Darshana Patil1Amit Bhatt2Rucha Dhasare3Vineet Datta4Rajan Datar5Dadasaheb Akolkar6Avinash Cancer Clinic, Tilak Road, Pantancha Gate, Sadashiv Peth, Pune 411030, Maharashtra, IndiaDatar Cancer Genetics Ltd., F-8 D-Road, Ambad, Nasik 422010, Maharashtra, IndiaAvinash Cancer Clinic, Tilak Road, Pantancha Gate, Sadashiv Peth, Pune 411030, Maharashtra, IndiaAvinash Cancer Clinic, Tilak Road, Pantancha Gate, Sadashiv Peth, Pune 411030, Maharashtra, IndiaDatar Cancer Genetics Ltd., F-8 D-Road, Ambad, Nasik 422010, Maharashtra, IndiaDatar Cancer Genetics Ltd., F-8 D-Road, Ambad, Nasik 422010, Maharashtra, IndiaDatar Cancer Genetics Ltd., F-8 D-Road, Ambad, Nasik 422010, Maharashtra, IndiaIn this paper we report long-term therapy management based on iterative de novo molecular and cellular analysis in a case of metastatic non-small cell lung cancer (NSCLC), with prior history of treated colorectal cancer. In the described case temporal tumor evolution, emergent therapy resistance and disease recurrences were addressed via the administration of personalized label- and organ-agnostic treatments based on de novo tumor profiling. This adaptive and iterative treatment strategy countered disease progression at each instance and led to the durable regression of primary as well as metastatic lesions. Concurrently, serial evaluation of mutations in cell-free circulating tumor DNA (ctDNA) via liquid biopsy (LBx) was performed to monitor disease status, ascertain treatment response, identify emergent drug resistance and detect recurrence at sub-radiological levels. The treatment management strategy described herein effectively addressed multiple, sequential clinical conundrums for which viable options were unavailable under the current Standard of Care (SoC).https://www.mdpi.com/2075-4426/9/3/34non small cell lung cancer (NSCLC)precision oncologypersonalized therapy management |
| spellingShingle | Anantbhushan Ranade Darshana Patil Amit Bhatt Rucha Dhasare Vineet Datta Rajan Datar Dadasaheb Akolkar Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC Journal of Personalized Medicine non small cell lung cancer (NSCLC) precision oncology personalized therapy management |
| title | Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC |
| title_full | Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC |
| title_fullStr | Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC |
| title_full_unstemmed | Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC |
| title_short | Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC |
| title_sort | adaptive iterative long term personalized therapy management in a case of stage iv refractory nsclc |
| topic | non small cell lung cancer (NSCLC) precision oncology personalized therapy management |
| url | https://www.mdpi.com/2075-4426/9/3/34 |
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