The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study
Background and aimsHyperthyroidism is an endocrine disease with multiple etiologies and manifestations. Heart failure (HF) is a common, costly, and deadly medical condition in clinical practice. Numerous studies have suggested that abnormal thyroid function can induce or aggravate the development of...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1344282/full |
| _version_ | 1797213534949474304 |
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| author | Jun Liu Jun Liu Gujie Wu Shuqi Li Lin Cheng Xinping Ye |
| author_facet | Jun Liu Jun Liu Gujie Wu Shuqi Li Lin Cheng Xinping Ye |
| author_sort | Jun Liu |
| collection | DOAJ |
| description | Background and aimsHyperthyroidism is an endocrine disease with multiple etiologies and manifestations. Heart failure (HF) is a common, costly, and deadly medical condition in clinical practice. Numerous studies have suggested that abnormal thyroid function can induce or aggravate the development of heart disease. However, no study has demonstrated a causal relationship between hyperthyroidism and heart failure. Therefore, the purpose of this study was to explore the causal link between hyperthyroidism and HF.MethodsSummary data for genetically predicted hyperthyroidism were obtained from a genetic association study. The data examined for genetically determined all-cause heart failure came from 218,208 individuals from the FinnGen Consortium. Two-sample Mendelian randomization (MR) analysis was used to estimate the causal link between hyperthyroidism and heart failure. Statistical analyses were conducted using the inverse variance-weighted, weighted median, simple median, weighted mode, MR-PRESSO (number of distribution = 5000), MR-Egger, and leave-one-out.ResultsThe results of the inverse-variance weighted analysis indicated a causal association between hyperthyroidism and an increased risk of all-cause heart failure (IVW: β=0.048, OR=1.049, 95%CI: [1.013 to 1.087], P=0.007). Similarly, the weighted median approach demonstrated a positive correlation between hyperthyroidism and all-cause heart failure (OR=1.049, [95% CI, 1.001-1.100]; P=0.044). Additionally, no horizontal pleiotropy or heterogeneity was observed. The leave-one-out analysis revealed that the majority of the SNP-driven associations were not influenced by a single genetic marker.ConclusionOur study observed a causal relationship between hyperthyroidism and all-cause heart failure. Hyperthyroidism may associate with heart failure genetically. |
| first_indexed | 2024-04-24T10:59:49Z |
| format | Article |
| id | doaj.art-7bc4c24c92f348d4906dc3aa4e065b78 |
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| language | English |
| last_indexed | 2024-04-24T10:59:49Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7bc4c24c92f348d4906dc3aa4e065b782024-04-12T04:12:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13442821344282The genetic association between hyperthyroidism and heart failure: a Mendelian randomization studyJun Liu0Jun Liu1Gujie Wu2Shuqi Li3Lin Cheng4Xinping Ye5Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaRegenerative Medicine Institute, School of Medicine, National University of Ireland (NUI), Galway, IrelandDepartment of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaBackground and aimsHyperthyroidism is an endocrine disease with multiple etiologies and manifestations. Heart failure (HF) is a common, costly, and deadly medical condition in clinical practice. Numerous studies have suggested that abnormal thyroid function can induce or aggravate the development of heart disease. However, no study has demonstrated a causal relationship between hyperthyroidism and heart failure. Therefore, the purpose of this study was to explore the causal link between hyperthyroidism and HF.MethodsSummary data for genetically predicted hyperthyroidism were obtained from a genetic association study. The data examined for genetically determined all-cause heart failure came from 218,208 individuals from the FinnGen Consortium. Two-sample Mendelian randomization (MR) analysis was used to estimate the causal link between hyperthyroidism and heart failure. Statistical analyses were conducted using the inverse variance-weighted, weighted median, simple median, weighted mode, MR-PRESSO (number of distribution = 5000), MR-Egger, and leave-one-out.ResultsThe results of the inverse-variance weighted analysis indicated a causal association between hyperthyroidism and an increased risk of all-cause heart failure (IVW: β=0.048, OR=1.049, 95%CI: [1.013 to 1.087], P=0.007). Similarly, the weighted median approach demonstrated a positive correlation between hyperthyroidism and all-cause heart failure (OR=1.049, [95% CI, 1.001-1.100]; P=0.044). Additionally, no horizontal pleiotropy or heterogeneity was observed. The leave-one-out analysis revealed that the majority of the SNP-driven associations were not influenced by a single genetic marker.ConclusionOur study observed a causal relationship between hyperthyroidism and all-cause heart failure. Hyperthyroidism may associate with heart failure genetically.https://www.frontiersin.org/articles/10.3389/fendo.2024.1344282/fullthyroid diseasehyperthyroidismheart failureall-cause heart failuretwo-sample Mendelian randomization (MR)SNPs |
| spellingShingle | Jun Liu Jun Liu Gujie Wu Shuqi Li Lin Cheng Xinping Ye The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study Frontiers in Endocrinology thyroid disease hyperthyroidism heart failure all-cause heart failure two-sample Mendelian randomization (MR) SNPs |
| title | The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study |
| title_full | The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study |
| title_fullStr | The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study |
| title_full_unstemmed | The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study |
| title_short | The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study |
| title_sort | genetic association between hyperthyroidism and heart failure a mendelian randomization study |
| topic | thyroid disease hyperthyroidism heart failure all-cause heart failure two-sample Mendelian randomization (MR) SNPs |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1344282/full |
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