Role of the immunosuppressive microenvironment in immunotherapy
Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109418301507 |
| _version_ | 1811295709285056512 |
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| author | Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD |
| author_facet | Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD |
| author_sort | Garth W. Tormoen, MD, PhD |
| collection | DOAJ |
| description | Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors. |
| first_indexed | 2024-04-13T05:37:30Z |
| format | Article |
| id | doaj.art-7bc68c29409c4958b3fd022c9555f0a5 |
| institution | Directory Open Access Journal |
| issn | 2452-1094 |
| language | English |
| last_indexed | 2024-04-13T05:37:30Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj.art-7bc68c29409c4958b3fd022c9555f0a52022-12-22T03:00:14ZengElsevierAdvances in Radiation Oncology2452-10942018-10-0134520526Role of the immunosuppressive microenvironment in immunotherapyGarth W. Tormoen, MD, PhD0Marka R. Crittenden, MD, PhD1Michael J. Gough, PhD2Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon; Corresponding author. Oregon Health and Science University, Department of Radiation Medicine, 3181 SW Sam Jackson Parkway, Portland, OR 97239.Earl A. Chiles Research Institute, Providence Portland Medical Center, Portland, Oregon; The Oregon Clinic, Portland, OregonEarl A. Chiles Research Institute, Providence Portland Medical Center, Portland, OregonImmunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors.http://www.sciencedirect.com/science/article/pii/S2452109418301507 |
| spellingShingle | Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD Role of the immunosuppressive microenvironment in immunotherapy Advances in Radiation Oncology |
| title | Role of the immunosuppressive microenvironment in immunotherapy |
| title_full | Role of the immunosuppressive microenvironment in immunotherapy |
| title_fullStr | Role of the immunosuppressive microenvironment in immunotherapy |
| title_full_unstemmed | Role of the immunosuppressive microenvironment in immunotherapy |
| title_short | Role of the immunosuppressive microenvironment in immunotherapy |
| title_sort | role of the immunosuppressive microenvironment in immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452109418301507 |
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